When enough is now too much: Fatal forty DDI: Midazolam, itraconazole, CYP3A4

Erica D. Wittwer; Juraj Sprung; Wayne T. Nicholson

doi:10.1007/978-1-4614-7495-1_81

When enough is now too much: Fatal forty DDI: Midazolam, itraconazole, CYP3A4

Erica D. Wittwer, Juraj Sprung, Wayne T. Nicholson

Anesthesiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses the pharmacokinetic interaction between midazolam and itraconazole, resulting in increased sedation. Midazolam is a cytochrome P450 3A4 substrate and itraconazole is a 3A4 inhibitor.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	381-384
Number of pages	4
ISBN (Print)	9781461474951, 9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_81
State	Published - Sep 15 2015

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-7495-1_81

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abstract = "This case discusses the pharmacokinetic interaction between midazolam and itraconazole, resulting in increased sedation. Midazolam is a cytochrome P450 3A4 substrate and itraconazole is a 3A4 inhibitor.",

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When enough is now too much: Fatal forty DDI: Midazolam, itraconazole, CYP3A4

Abstract

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