When enough is now too much: Fatal forty DDI: Midazolam, itraconazole, CYP3A4

Erica D. Wittwer, Juraj Sprung, Wayne T. Nicholson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses the pharmacokinetic interaction between midazolam and itraconazole, resulting in increased sedation. Midazolam is a cytochrome P450 3A4 substrate and itraconazole is a 3A4 inhibitor.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages381-384
Number of pages4
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

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Cytochrome P-450 CYP3A
Itraconazole
Midazolam
Pharmacokinetics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wittwer, E. D., Sprung, J., & Nicholson, W. T. (2015). When enough is now too much: Fatal forty DDI: Midazolam, itraconazole, CYP3A4. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 381-384). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_81

When enough is now too much : Fatal forty DDI: Midazolam, itraconazole, CYP3A4. / Wittwer, Erica D.; Sprung, Juraj; Nicholson, Wayne T.

A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 381-384.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wittwer, ED, Sprung, J & Nicholson, WT 2015, When enough is now too much: Fatal forty DDI: Midazolam, itraconazole, CYP3A4. in A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, pp. 381-384. https://doi.org/10.1007/978-1-4614-7495-1_81
Wittwer ED, Sprung J, Nicholson WT. When enough is now too much: Fatal forty DDI: Midazolam, itraconazole, CYP3A4. In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York. 2015. p. 381-384 https://doi.org/10.1007/978-1-4614-7495-1_81
Wittwer, Erica D. ; Sprung, Juraj ; Nicholson, Wayne T. / When enough is now too much : Fatal forty DDI: Midazolam, itraconazole, CYP3A4. A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. pp. 381-384
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