When are apparently non-clonal abnormalities in bone marrow chromosome studies actually clonal?

Chandra Hutchens, Rhett P. Ketterling, Daniel L. Van Dyke

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The observation of an apparently non-clonal abnormal cell in a cytogenetic study for a hematologic neoplasm opens the possibility of a small, or slowly proliferating, abnormal clone. Many laboratories analyze additional cells or reflex to fluorescence in situ hybridization (FISH) to evaluate this possibility further. In a retrospective study of 500 cases with a non-clonal abnormal cell identified in a 20-cell analysis, we found that the benefit of additional metaphase analysis was limited to specific categories of abnormal karyotypes, including those with a complex karyotype or a classic abnormality known to be a recurring finding in hematologic neoplasms, and excluding all other categories.

Original languageEnglish (US)
Pages (from-to)405-409
Number of pages5
JournalCancer Genetics
Volume205
Issue number7-8
DOIs
StatePublished - Jul 1 2012

Keywords

  • Cytogenetics
  • MDS
  • Myelodysplasia
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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