What to expect with major vascular reconstruction during Whipple procedures: A single institution experience and literature review

Matthew S. Jorgensen, Tariq Almerey, Houssam Farres, W. Andrew Oldenburg, John Stauffer, Albert Hakaim

Research output: Contribution to journalReview article

Abstract

Background: Major vascular reconstruction during a pancreaticoduodenectomy (PD), also known as a Whipple procedure, leads to controversial postoperative outcomes compared to conventional Whipple. Discussion with the patient regarding postoperative expectations is a crucial component of holistic surgical healthcare. The aim of this study was to report our 8-year experience of Whipple procedures involving vascular reconstruction and to review relevant literature to further evaluate expectant outcomes, therefore leading to more accurate discussion. Methods: A retrospective review of patients undergoing Whipple procedures from January 2010, through December 2017 was performed. Patch, graft, and primary anastomosis during Whipple procedures were considered major vascular reconstruction. Literature on the current understanding of the outcomes associated with vascular reconstruction during Whipple procedures was reviewed. Results: Twenty-nine from a total of 405 patients that met inclusion criteria had a Whipple procedure that involved major vascular reconstruction. Twelve patients were male and 17 were female (mean age, 65.2 years). Median hospital and intensive care unit (ICU) stay [range] of patients with vascular reconstruction was 12 [5–92] days and 3 [0–59] days, respectively. Thirty-day survival and 1-year survival of patients with vascular reconstruction was 93.1% and 55.2%, respectively, compared to non-vascular reconstruction patients 96.0% and 83.5%, respectively (P=0.35, P<0.001). Ninety-day readmission for vascular reconstruction patients was 31.0% compared to 14.6% in non-vascular reconstruction patients (P=0.03). The 1-year survival of those who had patch reconstruction, graft reconstruction, and primary anastomosis was 50.0%, 62.5%, 53.8%, respectively. Conclusions: Compared to conventional Whipple procedures, those requiring major vascular reconstruction are associated with decreased survival. When vascular reconstruction is a valid option patients should be well aware of the associated outcomes.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalJournal of Gastrointestinal Oncology
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2019

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Blood Vessels
Survival
Transplants
Pancreaticoduodenectomy
Intensive Care Units
Delivery of Health Care

Keywords

  • Pancreatic cancer
  • Survival
  • Vascular reconstruction
  • Whipple

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

What to expect with major vascular reconstruction during Whipple procedures : A single institution experience and literature review. / Jorgensen, Matthew S.; Almerey, Tariq; Farres, Houssam; Andrew Oldenburg, W.; Stauffer, John; Hakaim, Albert.

In: Journal of Gastrointestinal Oncology, Vol. 10, No. 1, 01.02.2019, p. 95-102.

Research output: Contribution to journalReview article

Jorgensen, Matthew S. ; Almerey, Tariq ; Farres, Houssam ; Andrew Oldenburg, W. ; Stauffer, John ; Hakaim, Albert. / What to expect with major vascular reconstruction during Whipple procedures : A single institution experience and literature review. In: Journal of Gastrointestinal Oncology. 2019 ; Vol. 10, No. 1. pp. 95-102.
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title = "What to expect with major vascular reconstruction during Whipple procedures: A single institution experience and literature review",
abstract = "Background: Major vascular reconstruction during a pancreaticoduodenectomy (PD), also known as a Whipple procedure, leads to controversial postoperative outcomes compared to conventional Whipple. Discussion with the patient regarding postoperative expectations is a crucial component of holistic surgical healthcare. The aim of this study was to report our 8-year experience of Whipple procedures involving vascular reconstruction and to review relevant literature to further evaluate expectant outcomes, therefore leading to more accurate discussion. Methods: A retrospective review of patients undergoing Whipple procedures from January 2010, through December 2017 was performed. Patch, graft, and primary anastomosis during Whipple procedures were considered major vascular reconstruction. Literature on the current understanding of the outcomes associated with vascular reconstruction during Whipple procedures was reviewed. Results: Twenty-nine from a total of 405 patients that met inclusion criteria had a Whipple procedure that involved major vascular reconstruction. Twelve patients were male and 17 were female (mean age, 65.2 years). Median hospital and intensive care unit (ICU) stay [range] of patients with vascular reconstruction was 12 [5–92] days and 3 [0–59] days, respectively. Thirty-day survival and 1-year survival of patients with vascular reconstruction was 93.1{\%} and 55.2{\%}, respectively, compared to non-vascular reconstruction patients 96.0{\%} and 83.5{\%}, respectively (P=0.35, P<0.001). Ninety-day readmission for vascular reconstruction patients was 31.0{\%} compared to 14.6{\%} in non-vascular reconstruction patients (P=0.03). The 1-year survival of those who had patch reconstruction, graft reconstruction, and primary anastomosis was 50.0{\%}, 62.5{\%}, 53.8{\%}, respectively. Conclusions: Compared to conventional Whipple procedures, those requiring major vascular reconstruction are associated with decreased survival. When vascular reconstruction is a valid option patients should be well aware of the associated outcomes.",
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T1 - What to expect with major vascular reconstruction during Whipple procedures

T2 - A single institution experience and literature review

AU - Jorgensen, Matthew S.

AU - Almerey, Tariq

AU - Farres, Houssam

AU - Andrew Oldenburg, W.

AU - Stauffer, John

AU - Hakaim, Albert

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: Major vascular reconstruction during a pancreaticoduodenectomy (PD), also known as a Whipple procedure, leads to controversial postoperative outcomes compared to conventional Whipple. Discussion with the patient regarding postoperative expectations is a crucial component of holistic surgical healthcare. The aim of this study was to report our 8-year experience of Whipple procedures involving vascular reconstruction and to review relevant literature to further evaluate expectant outcomes, therefore leading to more accurate discussion. Methods: A retrospective review of patients undergoing Whipple procedures from January 2010, through December 2017 was performed. Patch, graft, and primary anastomosis during Whipple procedures were considered major vascular reconstruction. Literature on the current understanding of the outcomes associated with vascular reconstruction during Whipple procedures was reviewed. Results: Twenty-nine from a total of 405 patients that met inclusion criteria had a Whipple procedure that involved major vascular reconstruction. Twelve patients were male and 17 were female (mean age, 65.2 years). Median hospital and intensive care unit (ICU) stay [range] of patients with vascular reconstruction was 12 [5–92] days and 3 [0–59] days, respectively. Thirty-day survival and 1-year survival of patients with vascular reconstruction was 93.1% and 55.2%, respectively, compared to non-vascular reconstruction patients 96.0% and 83.5%, respectively (P=0.35, P<0.001). Ninety-day readmission for vascular reconstruction patients was 31.0% compared to 14.6% in non-vascular reconstruction patients (P=0.03). The 1-year survival of those who had patch reconstruction, graft reconstruction, and primary anastomosis was 50.0%, 62.5%, 53.8%, respectively. Conclusions: Compared to conventional Whipple procedures, those requiring major vascular reconstruction are associated with decreased survival. When vascular reconstruction is a valid option patients should be well aware of the associated outcomes.

AB - Background: Major vascular reconstruction during a pancreaticoduodenectomy (PD), also known as a Whipple procedure, leads to controversial postoperative outcomes compared to conventional Whipple. Discussion with the patient regarding postoperative expectations is a crucial component of holistic surgical healthcare. The aim of this study was to report our 8-year experience of Whipple procedures involving vascular reconstruction and to review relevant literature to further evaluate expectant outcomes, therefore leading to more accurate discussion. Methods: A retrospective review of patients undergoing Whipple procedures from January 2010, through December 2017 was performed. Patch, graft, and primary anastomosis during Whipple procedures were considered major vascular reconstruction. Literature on the current understanding of the outcomes associated with vascular reconstruction during Whipple procedures was reviewed. Results: Twenty-nine from a total of 405 patients that met inclusion criteria had a Whipple procedure that involved major vascular reconstruction. Twelve patients were male and 17 were female (mean age, 65.2 years). Median hospital and intensive care unit (ICU) stay [range] of patients with vascular reconstruction was 12 [5–92] days and 3 [0–59] days, respectively. Thirty-day survival and 1-year survival of patients with vascular reconstruction was 93.1% and 55.2%, respectively, compared to non-vascular reconstruction patients 96.0% and 83.5%, respectively (P=0.35, P<0.001). Ninety-day readmission for vascular reconstruction patients was 31.0% compared to 14.6% in non-vascular reconstruction patients (P=0.03). The 1-year survival of those who had patch reconstruction, graft reconstruction, and primary anastomosis was 50.0%, 62.5%, 53.8%, respectively. Conclusions: Compared to conventional Whipple procedures, those requiring major vascular reconstruction are associated with decreased survival. When vascular reconstruction is a valid option patients should be well aware of the associated outcomes.

KW - Pancreatic cancer

KW - Survival

KW - Vascular reconstruction

KW - Whipple

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