What is the importance of abnormal "background" activity in seizure generation?

Richard J. Staba, Gregory A. Worrell

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Investigations of interictal epileptiform spikes and seizures have played a central role in the study of epilepsy. The background EEG activity, however, has received less attention. In this chapter we discuss the characteristic features of the background activity of the brain when individuals are at rest and awake (resting wake) and during sleep. The characteristic rhythms of the background EEG are presented, and the presence of 1/f β behavior of the EEG power spectral density is discussed and its possible origin and functional significance. The interictal EEG findings of focal epilepsy and the impact of interictal epileptiform spikes on cognition are also discussed.

Original languageEnglish (US)
Title of host publicationIssues in Clinical Epileptology
Subtitle of host publicationA View from the Bench
PublisherSpringer New York LLC
Pages43-54
Number of pages12
ISBN (Print)9789401789134
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume813
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Electroencephalogram
  • Epilepsy
  • High Frequency Oscillations
  • Local Field Potential Oscillations
  • Sleep

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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