What Is Responsible for Heterogeneity in Mantle Cell Lymphoma Biology and Outcomes?

Research output: Contribution to journalReview article

Abstract

Mantle cell lymphoma, despite its common derivation from a t(11;14) error that occurs in a naïve B-cell leading to overexpression of cyclin D1 protein, is characterized by substantial heterogeneity in biology and clinical outcome. Unlike other non-Hodgkin lymphoma types, it is more common in men. Clinical presentation patterns vary from nodal to splenomegaly with leukemia to gastrointestinal involvement. Biological variability is linked to tumor cell proliferation. Increased monocyte/macrophages and their associated proinflammatory cytokines are associated with inferior outcomes. These clues mandate that new treatments should target signal pathways that contribute to these adverse outcomes.

Original languageEnglish (US)
Pages (from-to)825-835
Number of pages11
JournalHematology/Oncology Clinics of North America
Volume34
Issue number5
DOIs
StateAccepted/In press - 2020

Keywords

  • Cell proliferation
  • Cytokines
  • Metabolomics
  • Minimal residual disease
  • TP53 mutation

ASJC Scopus subject areas

  • Hematology
  • Oncology

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