What has bariatric surgery taught us about the role of the upper gastrointestinal tract in the regulation of postprandial glucose metabolism?

Jing Ma, Adrian Vella

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The interaction between the upper gastrointestinal tract and the endocrine system is important in the regulation of metabolism and of weight. The gastrointestinal tract has a heterogeneous cellular content and comprises a variety of cells that elaborate paracrine and endocrine mediators that collectively form the entero-endocrine system. The advent of therapy that utilizes these pathways as well as the association of bariatric surgery with diabetes remission has (re-)kindled interest in the role of the gastrointestinal tract in glucose homeostasis. In this review, we will use the changes wrought by bariatric surgery to provide insights into the various gut-pancreas interactions that maintain weight, regulate satiety, and limit glucose excursions after meal ingestion.

Original languageEnglish (US)
Article number324
JournalFrontiers in Endocrinology
Volume9
Issue numberJUL
DOIs
StatePublished - Jun 26 2018

Keywords

  • Bariatric surgery
  • Gastric accommodation
  • Gastric emptying
  • Incretin hormones
  • Insulin action
  • Insulin secretion
  • Vagus nerve

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'What has bariatric surgery taught us about the role of the upper gastrointestinal tract in the regulation of postprandial glucose metabolism?'. Together they form a unique fingerprint.

  • Cite this