What Does PLIER Really Do?

Terry M. Therneau; Karla V. Ballman

doi:10.4137/117693510800600008

What Does PLIER Really Do?

Terry M. Therneau, Karla V. Ballman

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Motivation: Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption. Results: In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level error function does capture the key characteristics of the ideal error function, assuming MM probes only measure non-specific binding and no signal.

Original language	English (US)
Journal	Cancer Informatics
Volume	6
DOIs	https://doi.org/10.4137/117693510800600008
State	Published - 2008

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.4137/117693510800600008

Cite this

@article{ae11212834b04319af6950b950e4591e,

title = "What Does PLIER Really Do?",

abstract = "Motivation: Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption. Results: In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level error function does capture the key characteristics of the ideal error function, assuming MM probes only measure non-specific binding and no signal.",

author = "Therneau, {Terry M.} and Ballman, {Karla V.}",

note = "Publisher Copyright: {\textcopyright} 2008 SAGE Publications.",

year = "2008",

doi = "10.4137/117693510800600008",

language = "English (US)",

volume = "6",

journal = "Cancer Informatics",