What do I need to know about immunoglobulin light chain (AL) amyloidosis?

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Immunoglobulin light chain (AL) amyloidosis is the most common acquired systemic amyloidoses. Its presentation is often insidious and progressive, which may delay diagnosis. The interval between first symptoms and actual diagnosis along the intrinsic heterogeneity of tissue tropism create a wide spectrum of presentations, both in terms of scope and depth of symptoms and signs and functional status of patients. In this review, the authors review the pathogenesis, diagnosis and differential diagnosis of AL amyloidosis along with the prognosis and state-of-the-art management for patients with this affliction.

Original languageEnglish (US)
Pages (from-to)137-154
Number of pages18
JournalBlood Reviews
Volume26
Issue number4
DOIs
StatePublished - Jul 2012

Fingerprint

Immunoglobulin Light Chains
Amyloidosis
Tropism
Signs and Symptoms
Differential Diagnosis

Keywords

  • Amyloidosis
  • Monoclonal gammopathy
  • Multisystem disease
  • Prognosis
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

What do I need to know about immunoglobulin light chain (AL) amyloidosis? / Dispenzieri, Angela; Gertz, Morie; Buadi, Francis.

In: Blood Reviews, Vol. 26, No. 4, 07.2012, p. 137-154.

Research output: Contribution to journalArticle

@article{976a8f3560a44e70976845e1222882d3,
title = "What do I need to know about immunoglobulin light chain (AL) amyloidosis?",
abstract = "Immunoglobulin light chain (AL) amyloidosis is the most common acquired systemic amyloidoses. Its presentation is often insidious and progressive, which may delay diagnosis. The interval between first symptoms and actual diagnosis along the intrinsic heterogeneity of tissue tropism create a wide spectrum of presentations, both in terms of scope and depth of symptoms and signs and functional status of patients. In this review, the authors review the pathogenesis, diagnosis and differential diagnosis of AL amyloidosis along with the prognosis and state-of-the-art management for patients with this affliction.",
keywords = "Amyloidosis, Monoclonal gammopathy, Multisystem disease, Prognosis, Transplantation",
author = "Angela Dispenzieri and Morie Gertz and Francis Buadi",
year = "2012",
month = "7",
doi = "10.1016/j.blre.2012.03.001",
language = "English (US)",
volume = "26",
pages = "137--154",
journal = "Blood Reviews",
issn = "0268-960X",
publisher = "Churchill Livingstone",
number = "4",

}

TY - JOUR

T1 - What do I need to know about immunoglobulin light chain (AL) amyloidosis?

AU - Dispenzieri, Angela

AU - Gertz, Morie

AU - Buadi, Francis

PY - 2012/7

Y1 - 2012/7

N2 - Immunoglobulin light chain (AL) amyloidosis is the most common acquired systemic amyloidoses. Its presentation is often insidious and progressive, which may delay diagnosis. The interval between first symptoms and actual diagnosis along the intrinsic heterogeneity of tissue tropism create a wide spectrum of presentations, both in terms of scope and depth of symptoms and signs and functional status of patients. In this review, the authors review the pathogenesis, diagnosis and differential diagnosis of AL amyloidosis along with the prognosis and state-of-the-art management for patients with this affliction.

AB - Immunoglobulin light chain (AL) amyloidosis is the most common acquired systemic amyloidoses. Its presentation is often insidious and progressive, which may delay diagnosis. The interval between first symptoms and actual diagnosis along the intrinsic heterogeneity of tissue tropism create a wide spectrum of presentations, both in terms of scope and depth of symptoms and signs and functional status of patients. In this review, the authors review the pathogenesis, diagnosis and differential diagnosis of AL amyloidosis along with the prognosis and state-of-the-art management for patients with this affliction.

KW - Amyloidosis

KW - Monoclonal gammopathy

KW - Multisystem disease

KW - Prognosis

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=84861480962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861480962&partnerID=8YFLogxK

U2 - 10.1016/j.blre.2012.03.001

DO - 10.1016/j.blre.2012.03.001

M3 - Article

VL - 26

SP - 137

EP - 154

JO - Blood Reviews

JF - Blood Reviews

SN - 0268-960X

IS - 4

ER -