What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us about the Pathogenesis of Type 2 Diabetes?

J. D. Adams, Adrian Vella

Research output: Contribution to journalReview article

3 Scopus citations


Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disorder characterized by hyperglycemia occurring as a result of impaired insulin secretion and/or insulin resistance. Among the various genetic factors associated with T2DM, a common genetic variant within the transcription factor 7-like 2 locus (TCF7L2) confers the greatest genetic risk for development of the disease. However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain. Here we review the current literature pertaining to the potential mechanisms by which TCF7L2 confers risk of T2DM, using genetic variation as a probe to understand the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)383-389
Number of pages7
JournalMetabolic Syndrome and Related Disorders
Issue number8
StatePublished - Oct 1 2018



  • common genetic variation
  • insulin action
  • insulin secretion
  • type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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