Well‐differentiated lymphocytic lymphoma. A study of 47 patients with primary manifestation in the lung

Roderick R. Turner; Thomas V. Colby; Reuben S. Doggett

doi:10.1002/1097-0142(19841115)54:10<2088::AID-CNCR2820541008>3.0.CO;2-Y

Well‐differentiated lymphocytic lymphoma. A study of 47 patients with primary manifestation in the lung

Roderick R. Turner, Thomas V. Colby, Reuben S. Doggett

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Forty‐seven cases of primary well‐differentiated lymphocytic lymphoma (WDL) of the lung were studied. Diagnosis was based on histologic identification of a lymphangitic pattern of infiltration and monomorphous (homogenous) cytologic composition. Nineteen cases (40%) had ancillary evidence supportive of a diagnosis of lymphoma including simultaneous or subsequent involvement of other organs, monoclonal immunologic markers, or a monoclonal serum gammopathy. The prognosis for the group as a whole was excellent; follow‐up (median, 4 years) was available for 33 cases. Only one patient has died of lymphoma. The authors discuss the histologic differential diagnosis of lymphocytic infiltrates in the lung, propose criteria to distinguish reactive from neoplastic lymphocytic lesions, and discuss the significance of monoclonality in the management of these patients.

Original language	English (US)
Pages (from-to)	2088-2096
Number of pages	9
Journal	Cancer
Volume	54
Issue number	10
DOIs	https://doi.org/10.1002/1097-0142(19841115)54:10<2088::AID-CNCR2820541008>3.0.CO;2-Y
State	Published - Nov 15 1984

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19841115)54:10<2088::AID-CNCR2820541008>3.0.CO;2-Y

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abstract = "Forty‐seven cases of primary well‐differentiated lymphocytic lymphoma (WDL) of the lung were studied. Diagnosis was based on histologic identification of a lymphangitic pattern of infiltration and monomorphous (homogenous) cytologic composition. Nineteen cases (40%) had ancillary evidence supportive of a diagnosis of lymphoma including simultaneous or subsequent involvement of other organs, monoclonal immunologic markers, or a monoclonal serum gammopathy. The prognosis for the group as a whole was excellent; follow‐up (median, 4 years) was available for 33 cases. Only one patient has died of lymphoma. The authors discuss the histologic differential diagnosis of lymphocytic infiltrates in the lung, propose criteria to distinguish reactive from neoplastic lymphocytic lesions, and discuss the significance of monoclonality in the management of these patients.",

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AU - Doggett, Reuben S.

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N2 - Forty‐seven cases of primary well‐differentiated lymphocytic lymphoma (WDL) of the lung were studied. Diagnosis was based on histologic identification of a lymphangitic pattern of infiltration and monomorphous (homogenous) cytologic composition. Nineteen cases (40%) had ancillary evidence supportive of a diagnosis of lymphoma including simultaneous or subsequent involvement of other organs, monoclonal immunologic markers, or a monoclonal serum gammopathy. The prognosis for the group as a whole was excellent; follow‐up (median, 4 years) was available for 33 cases. Only one patient has died of lymphoma. The authors discuss the histologic differential diagnosis of lymphocytic infiltrates in the lung, propose criteria to distinguish reactive from neoplastic lymphocytic lesions, and discuss the significance of monoclonality in the management of these patients.

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Well‐differentiated lymphocytic lymphoma. A study of 47 patients with primary manifestation in the lung

Abstract

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