Weight change after smoking cessation using variable doses of transdermal nicotine replacement

Lowell C. Dale, Darrell R. Schroeder, Troy D. Wolter, Ivana T Croghan, Richard D. Hurt, Kenneth P. Offord

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

OBJECTIVE: Examine weight change in subjects receiving variable doses of transdermal nicotine replacement for smoking cessation. DESIGN: Randomized, double-blind clinical trial. SETTING: One-week inpatient treatment with outpatient follow-up through 1 year. INTERVENTION: This report examines weight change after smoking cessation for 70 subjects randomized to placebo or to 11, 22, or 44 mg/d doses of transdermal nicotine. The study included 1 week of intensive inpatient treatment for nicotine dependence with active patch therapy continuing for another 7 weeks. Counseling sessions were provided weekly for the 8 weeks of patch therapy and with long-term follow- up visits at 3, 6, 9, and 12 months. MEASUREMENTS AND MAIN RESULTS: Forty- two subjects were confirmed biochemically (i.e., by expired carbon monoxide) to be nonsmokers at all weekly visits during patch therapy. Their 8-week weight change from baseline was 3.0 ± 2.0 kg. For these subjects, 8-week weight change was found to be negatively correlated with percentage of cotinine replacement (r = -.38, p = .012) and positively correlated with baseline weight (r = .48, p = .001), and age (r = .35, p = .025). Men had higher (p = .003) 8-week weight gain (4.0 ± 1.8 kg) than women (2.1 ± 1.7 kg). Of the 21 subjects who abstained continuously for the entire year, 20 had their weight measured at 1-year follow-up. Among these 20 subjects, 1- year weight change was not found to be associated with gender, baseline weight, baseline smoking rate, total dose of transdermal nicotine, or average percentage of cotinine replacement during the 8 weeks of patch therapy. CONCLUSIONS: This study suggests that higher replacement levels of nicotine may delay postcessation weight gain. This effect is consistent for both men end women. We could not identify any factors that predict weight change with longterm abstinence from smoking.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalJournal of General Internal Medicine
Volume13
Issue number1
DOIs
StatePublished - 1998

Fingerprint

Smoking Cessation
Nicotine
Weights and Measures
Cotinine
Weight Gain
Inpatients
Therapeutics
Smoking
Tobacco Use Disorder
Carbon Monoxide
Counseling
Outpatients
Placebos
Clinical Trials

Keywords

  • Nicotine patch
  • Smoking cessation
  • Weight

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Weight change after smoking cessation using variable doses of transdermal nicotine replacement. / Dale, Lowell C.; Schroeder, Darrell R.; Wolter, Troy D.; Croghan, Ivana T; Hurt, Richard D.; Offord, Kenneth P.

In: Journal of General Internal Medicine, Vol. 13, No. 1, 1998, p. 9-15.

Research output: Contribution to journalArticle

Dale, Lowell C. ; Schroeder, Darrell R. ; Wolter, Troy D. ; Croghan, Ivana T ; Hurt, Richard D. ; Offord, Kenneth P. / Weight change after smoking cessation using variable doses of transdermal nicotine replacement. In: Journal of General Internal Medicine. 1998 ; Vol. 13, No. 1. pp. 9-15.
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AB - OBJECTIVE: Examine weight change in subjects receiving variable doses of transdermal nicotine replacement for smoking cessation. DESIGN: Randomized, double-blind clinical trial. SETTING: One-week inpatient treatment with outpatient follow-up through 1 year. INTERVENTION: This report examines weight change after smoking cessation for 70 subjects randomized to placebo or to 11, 22, or 44 mg/d doses of transdermal nicotine. The study included 1 week of intensive inpatient treatment for nicotine dependence with active patch therapy continuing for another 7 weeks. Counseling sessions were provided weekly for the 8 weeks of patch therapy and with long-term follow- up visits at 3, 6, 9, and 12 months. MEASUREMENTS AND MAIN RESULTS: Forty- two subjects were confirmed biochemically (i.e., by expired carbon monoxide) to be nonsmokers at all weekly visits during patch therapy. Their 8-week weight change from baseline was 3.0 ± 2.0 kg. For these subjects, 8-week weight change was found to be negatively correlated with percentage of cotinine replacement (r = -.38, p = .012) and positively correlated with baseline weight (r = .48, p = .001), and age (r = .35, p = .025). Men had higher (p = .003) 8-week weight gain (4.0 ± 1.8 kg) than women (2.1 ± 1.7 kg). Of the 21 subjects who abstained continuously for the entire year, 20 had their weight measured at 1-year follow-up. Among these 20 subjects, 1- year weight change was not found to be associated with gender, baseline weight, baseline smoking rate, total dose of transdermal nicotine, or average percentage of cotinine replacement during the 8 weeks of patch therapy. CONCLUSIONS: This study suggests that higher replacement levels of nicotine may delay postcessation weight gain. This effect is consistent for both men end women. We could not identify any factors that predict weight change with longterm abstinence from smoking.

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