Wegener's granulomatosis presenting as subglottic stenosis

Mayra Guerrero, E. Gall, E. Tilahun, J. Garon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Wegener's granulomatosis is an uncommon disease process that causes necrotizing vasculitis predominantly in the lungs, kidneys, and upper airways. Subglottic stenosis has been observed in up to 20% of patients with established diagnosis of Wegener's granulomatosis, but it is rarely the initial manifestation of the disease. This case report presents a patient with Wegener's granulomatosis who had subglottic stenosis as predominant initial manifestation, without signs of lung or kidney involvement. The diagnosis was unclear initially due to the absence of damage to these organs and to the nonspecificity of the initial biopsy findings. After stabilizing the patient, an elevated cytoplasmic pattern of antineutrophil cytoplasmic antibodies titer was obtained, which played an important role in the diagnostic process and led to a second biopsy that showed vasculitis. The patient had an excellent response to prednisone, methotrexate, and trimethoprim/sulfamethoxazole, but as with many such cases, she also required tracheolaryngoplasty.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalJournal of Clinical Rheumatology
Volume7
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Granulomatosis with Polyangiitis
Pathologic Constriction
Vasculitis
Kidney
Biopsy
Lung
Antineutrophil Cytoplasmic Antibodies
Sulfamethoxazole Drug Combination Trimethoprim
Prednisone
Methotrexate

Keywords

  • Subglottic stenosis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Wegener's granulomatosis presenting as subglottic stenosis. / Guerrero, Mayra; Gall, E.; Tilahun, E.; Garon, J.

In: Journal of Clinical Rheumatology, Vol. 7, No. 2, 01.01.2001, p. 91-96.

Research output: Contribution to journalArticle

Guerrero, Mayra ; Gall, E. ; Tilahun, E. ; Garon, J. / Wegener's granulomatosis presenting as subglottic stenosis. In: Journal of Clinical Rheumatology. 2001 ; Vol. 7, No. 2. pp. 91-96.
@article{f2455910f8af455390c917ade7f050e5,
title = "Wegener's granulomatosis presenting as subglottic stenosis",
abstract = "Wegener's granulomatosis is an uncommon disease process that causes necrotizing vasculitis predominantly in the lungs, kidneys, and upper airways. Subglottic stenosis has been observed in up to 20{\%} of patients with established diagnosis of Wegener's granulomatosis, but it is rarely the initial manifestation of the disease. This case report presents a patient with Wegener's granulomatosis who had subglottic stenosis as predominant initial manifestation, without signs of lung or kidney involvement. The diagnosis was unclear initially due to the absence of damage to these organs and to the nonspecificity of the initial biopsy findings. After stabilizing the patient, an elevated cytoplasmic pattern of antineutrophil cytoplasmic antibodies titer was obtained, which played an important role in the diagnostic process and led to a second biopsy that showed vasculitis. The patient had an excellent response to prednisone, methotrexate, and trimethoprim/sulfamethoxazole, but as with many such cases, she also required tracheolaryngoplasty.",
keywords = "Subglottic stenosis, Wegener's granulomatosis",
author = "Mayra Guerrero and E. Gall and E. Tilahun and J. Garon",
year = "2001",
month = "1",
day = "1",
doi = "10.1097/00124743-200104000-00008",
language = "English (US)",
volume = "7",
pages = "91--96",
journal = "Journal of Clinical Rheumatology",
issn = "1076-1608",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Wegener's granulomatosis presenting as subglottic stenosis

AU - Guerrero, Mayra

AU - Gall, E.

AU - Tilahun, E.

AU - Garon, J.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Wegener's granulomatosis is an uncommon disease process that causes necrotizing vasculitis predominantly in the lungs, kidneys, and upper airways. Subglottic stenosis has been observed in up to 20% of patients with established diagnosis of Wegener's granulomatosis, but it is rarely the initial manifestation of the disease. This case report presents a patient with Wegener's granulomatosis who had subglottic stenosis as predominant initial manifestation, without signs of lung or kidney involvement. The diagnosis was unclear initially due to the absence of damage to these organs and to the nonspecificity of the initial biopsy findings. After stabilizing the patient, an elevated cytoplasmic pattern of antineutrophil cytoplasmic antibodies titer was obtained, which played an important role in the diagnostic process and led to a second biopsy that showed vasculitis. The patient had an excellent response to prednisone, methotrexate, and trimethoprim/sulfamethoxazole, but as with many such cases, she also required tracheolaryngoplasty.

AB - Wegener's granulomatosis is an uncommon disease process that causes necrotizing vasculitis predominantly in the lungs, kidneys, and upper airways. Subglottic stenosis has been observed in up to 20% of patients with established diagnosis of Wegener's granulomatosis, but it is rarely the initial manifestation of the disease. This case report presents a patient with Wegener's granulomatosis who had subglottic stenosis as predominant initial manifestation, without signs of lung or kidney involvement. The diagnosis was unclear initially due to the absence of damage to these organs and to the nonspecificity of the initial biopsy findings. After stabilizing the patient, an elevated cytoplasmic pattern of antineutrophil cytoplasmic antibodies titer was obtained, which played an important role in the diagnostic process and led to a second biopsy that showed vasculitis. The patient had an excellent response to prednisone, methotrexate, and trimethoprim/sulfamethoxazole, but as with many such cases, she also required tracheolaryngoplasty.

KW - Subglottic stenosis

KW - Wegener's granulomatosis

UR - http://www.scopus.com/inward/record.url?scp=0035049788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035049788&partnerID=8YFLogxK

U2 - 10.1097/00124743-200104000-00008

DO - 10.1097/00124743-200104000-00008

M3 - Article

C2 - 17039103

AN - SCOPUS:0035049788

VL - 7

SP - 91

EP - 96

JO - Journal of Clinical Rheumatology

JF - Journal of Clinical Rheumatology

SN - 1076-1608

IS - 2

ER -