Wegener's granulomatosis associated with vasculitis of the temporal artery

Report of five cases

H. Nishino, R. A. DeRemee, F. A. Rubino, Joseph E Parisi

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Between January 1973 and October 1991 at the Mayo Clinic, 5 of 345 patients with Wegener's granulomatosis initially had features suggestive of giant cell arteritis and subsequently were found to have biopsy-proven vasculitis of the temporal artery. All five patients were older than 60 years of age and had jaw claudication, sudden loss of vision, severe headache with or without diplopia, or polymyalgia rheumatica at the time of initial examination. The erythrocyte sedimentation rate was high at the time of onset of symptoms in four patients (and unavailable in one patient). A temporal artery biopsy specimen revealed giant cell arteritis in one patient and non- giant cell arteritis in four patients. All five patients subsequently had pulmonary and renal lesions characteristic of Wegener's granulomatosis, with typical histopathologic features on biopsy or positive cytoplasmic staining antineutrophil cytoplasmic antibodies. Thus, overlapping features of giant cell arteritis and Wegener's granulomatosis do occur in some patients.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalMayo Clinic Proceedings
Volume68
Issue number2
StatePublished - 1993

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Temporal Arteries
Granulomatosis with Polyangiitis
Vasculitis
Giant Cell Arteritis
Biopsy
Polymyalgia Rheumatica
Antineutrophil Cytoplasmic Antibodies
Diplopia
Blood Sedimentation
Jaw
Headache
Staining and Labeling
Kidney
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nishino, H., DeRemee, R. A., Rubino, F. A., & Parisi, J. E. (1993). Wegener's granulomatosis associated with vasculitis of the temporal artery: Report of five cases. Mayo Clinic Proceedings, 68(2), 115-121.

Wegener's granulomatosis associated with vasculitis of the temporal artery : Report of five cases. / Nishino, H.; DeRemee, R. A.; Rubino, F. A.; Parisi, Joseph E.

In: Mayo Clinic Proceedings, Vol. 68, No. 2, 1993, p. 115-121.

Research output: Contribution to journalArticle

Nishino, H, DeRemee, RA, Rubino, FA & Parisi, JE 1993, 'Wegener's granulomatosis associated with vasculitis of the temporal artery: Report of five cases', Mayo Clinic Proceedings, vol. 68, no. 2, pp. 115-121.
Nishino, H. ; DeRemee, R. A. ; Rubino, F. A. ; Parisi, Joseph E. / Wegener's granulomatosis associated with vasculitis of the temporal artery : Report of five cases. In: Mayo Clinic Proceedings. 1993 ; Vol. 68, No. 2. pp. 115-121.
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