TY - JOUR
T1 - Walking a fine line between -cell secretion and proliferation
AU - Vella, Adrian
AU - Matveyenko, Aleksey
N1 - Funding Information:
This work was supported by NIDDK, National Institutes of Health Grants DK98468 (to A. M.) and DK78646 and DK116231 (to A. V.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health.
PY - 2018/9/7
Y1 - 2018/9/7
N2 - Of the many common genetic variants associated with type 2 diabetes, that in TCF7L2 remains the most studied because it has the greatest effect size. However, the mechanism by which this variant alters diabetes risk remains elusive. A new study adds another layer of complexity, suggesting that the effects of TCF7L2 are context-dependent, and highlights a novel interaction that might bias a -cell to a secretory or proliferative phenotype. This in turn might open up new avenues to the restoration of insulin secretion in people with type 2 diabetes.
AB - Of the many common genetic variants associated with type 2 diabetes, that in TCF7L2 remains the most studied because it has the greatest effect size. However, the mechanism by which this variant alters diabetes risk remains elusive. A new study adds another layer of complexity, suggesting that the effects of TCF7L2 are context-dependent, and highlights a novel interaction that might bias a -cell to a secretory or proliferative phenotype. This in turn might open up new avenues to the restoration of insulin secretion in people with type 2 diabetes.
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U2 - 10.1074/jbc.H118.005121
DO - 10.1074/jbc.H118.005121
M3 - Article
C2 - 30194258
AN - SCOPUS:85053019179
VL - 293
SP - 14190
EP - 14191
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 36
ER -