Waiting impulsivity during reward seeking increases adult hippocampal neurogenesis in mice

Lee Peyton, Alfredo Oliveros, Chang Hoon Cho, Phillip Starski, Daniel Lindberg, Mi-Hyeon D Jang, Doo Sup Choi

Research output: Contribution to journalArticle

Abstract

Impulsivity is defined as a predisposition toward rapid, unplanned reactions in response to internal or external stimuli, often yielding negative consequences. Accordingly, impulsivity is considered a significant risk factor for developing addictive behaviors. The hippocampus is involved in regulating behavioral adaptability and learned behaviors. Consequently, abnormal hippocampal function has been demonstrated to contribute to impulsive and addictive behaviors. Furthermore, differential reinforcement of low rates of behavior (DRL) has shown that the hippocampus is implicated in reward acquisition and impulsivity in humans and rodent models. We have previously shown that impulsive behavior potentiates hippocampal neuroblast proliferation. However, the fate of these precursor cells produced during impulsive reward seeking remains unknown. Here, we demonstrate that DRL-mediated impulsive reward seeking with the 2-choice reaction time task (2-CRTT) increases the number of BrdU labeled cells in the dentate gyrus region of the hippocampus. Importantly, our results also show a significant increase in BrdU + and NeuN + colocalized mature newborn neurons in mice exhibiting impulsivity compared to non-impulsive control mice. These results suggest that operant reward seeking during unpredictable schedules of reinforcement contributes to adult hippocampal neurogenesis.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalNeuroscience Letters
Volume706
DOIs
StatePublished - Jul 27 2019

Fingerprint

Impulsive Behavior
Neurogenesis
Reward
Addictive Behavior
Bromodeoxyuridine
Hippocampus
Reinforcement Schedule
Parahippocampal Gyrus
Dentate Gyrus
Reaction Time
Rodentia
Neurons

Keywords

  • Addiction
  • Hippocampus
  • Impulsivity
  • Neurogenesis
  • Operant conditioning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Waiting impulsivity during reward seeking increases adult hippocampal neurogenesis in mice. / Peyton, Lee; Oliveros, Alfredo; Cho, Chang Hoon; Starski, Phillip; Lindberg, Daniel; Jang, Mi-Hyeon D; Choi, Doo Sup.

In: Neuroscience Letters, Vol. 706, 27.07.2019, p. 169-175.

Research output: Contribution to journalArticle

Peyton, Lee ; Oliveros, Alfredo ; Cho, Chang Hoon ; Starski, Phillip ; Lindberg, Daniel ; Jang, Mi-Hyeon D ; Choi, Doo Sup. / Waiting impulsivity during reward seeking increases adult hippocampal neurogenesis in mice. In: Neuroscience Letters. 2019 ; Vol. 706. pp. 169-175.
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