Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva

John Kenneth Schoolmeester; Aaron J. Leifer; Lu Wang; Meera R. Hameed

doi:10.1097/PGP.0000000000000170

Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva

John Kenneth Schoolmeester, Aaron J. Leifer, Lu Wang, Meera R. Hameed

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization. Both cases are the first liposarcomas of this site to be confirmed by molecular cytogenetic analysis. We also review the literature's cases of liposarcoma to further examine the clinicopathologic features of these tumors.

Original language	English (US)
Pages (from-to)	390-395
Number of pages	6
Journal	International Journal of Gynecological Pathology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1097/PGP.0000000000000170
State	Published - Jun 24 2015

Keywords

Liposarcoma
Myxoid
Vulva

ASJC Scopus subject areas

Pathology and Forensic Medicine
Obstetrics and Gynecology

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10.1097/PGP.0000000000000170

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Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva. / Schoolmeester, John Kenneth; Leifer, Aaron J.; Wang, Lu et al.
In: International Journal of Gynecological Pathology, Vol. 34, No. 4, 24.06.2015, p. 390-395.

Research output: Contribution to journal › Article › peer-review

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abstract = "Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization. Both cases are the first liposarcomas of this site to be confirmed by molecular cytogenetic analysis. We also review the literature's cases of liposarcoma to further examine the clinicopathologic features of these tumors.",

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AU - Hameed, Meera R.

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N2 - Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization. Both cases are the first liposarcomas of this site to be confirmed by molecular cytogenetic analysis. We also review the literature's cases of liposarcoma to further examine the clinicopathologic features of these tumors.

AB - Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization. Both cases are the first liposarcomas of this site to be confirmed by molecular cytogenetic analysis. We also review the literature's cases of liposarcoma to further examine the clinicopathologic features of these tumors.

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Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva

Abstract

Keywords

ASJC Scopus subject areas

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