Vps9 domain-containing proteins: Activators of Rab5 GTPases from yeast to neurons

Darren S. Carney, Brian A. Davies, Bruce F. Horazdovsky

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


Endocytosis of cell surface receptors plays an important role in regulating cell signaling cascades. In some cases, internalization of an activated receptor attenuates the signaling process, while in other cases the clustering of activated receptors on early endosomal structures has been proposed to be essential for fully activating signaling cascades. Regulating the movement of receptors and other signaling proteins through the endocytic pathway, therefore, has a direct impact on cellular homeostasis. The small GTPase Rab5 is a crucial regulatory component of the endocytic pathway. Activation of Rab5 is mediated by GDP-GTP exchange factors (GEFs) that generate the Rab5-GTP complex. A large number of proteins have been identified that contain a specific, highly conserved domain (Vps9) that catalyzes nucleotide exchange on Rab5, linking the regulation of cell signaling cascades with intracellular receptor trafficking through the endocytic pathway.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalTrends in Cell Biology
Issue number1
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Cell Biology


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