Voxel-based morphometry in autopsy proven PSP and CBD

Keith A. Josephs; Jennifer L. Whitwell; Dennis W. Dickson; Bradley F. Boeve; David S. Knopman; Ronald C. Petersen; Joseph E. Parisi; Clifford R. Jack

doi:10.1016/j.neurobiolaging.2006.09.019

Voxel-based morphometry in autopsy proven PSP and CBD

Keith A. Josephs, Jennifer L. Whitwell, Dennis W. Dickson, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Joseph E. Parisi, Clifford R. Jack

Research output: Contribution to journal › Article › peer-review

168 Scopus citations

Abstract

The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.

Original language	English (US)
Pages (from-to)	280-289
Number of pages	10
Journal	Neurobiology of aging
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.neurobiolaging.2006.09.019
State	Published - Feb 2008

Keywords

Corticobasal degeneration
Dementia
Extrapyramidal
Grey matter
Magnetic resonance imaging
Parkinsonism
Pathology
Progressive supranuclear palsy
White matter

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2006.09.019

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@article{7e2a4777e9144758ba89af3cc58f0f68,

title = "Voxel-based morphometry in autopsy proven PSP and CBD",

abstract = "The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.",

keywords = "Corticobasal degeneration, Dementia, Extrapyramidal, Grey matter, Magnetic resonance imaging, Parkinsonism, Pathology, Progressive supranuclear palsy, White matter",

author = "Josephs, {Keith A.} and Whitwell, {Jennifer L.} and Dickson, {Dennis W.} and Boeve, {Bradley F.} and Knopman, {David S.} and Petersen, {Ronald C.} and Parisi, {Joseph E.} and Jack, {Clifford R.}",

note = "Funding Information: This study was supported by the NIH Roadmap Multidisciplinary Clinical Research Career Development Award Grant (K12/NICHD)-HD49078, by grants P50 AG16574, U01 AG06786 and R01 AG11378 from the National Institute on Aging, Bethesda MD, NIRG-03-4842 from the Alzheimer's Association, and the generous support of the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation, USA. The authors would like to thank Dennis Hanson from the Biomedical Imaging Resource, Mayo Clinic, for help with the 3D renders. All renders were performed with the Analyze 7.0 software program. The authors would also like to thanks Dr. J. Eric Ahlskog for critical review of this manuscript.",

year = "2008",

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doi = "10.1016/j.neurobiolaging.2006.09.019",

language = "English (US)",

volume = "29",

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journal = "Neurobiology of aging",

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T1 - Voxel-based morphometry in autopsy proven PSP and CBD

AU - Josephs, Keith A.

AU - Whitwell, Jennifer L.

AU - Dickson, Dennis W.

AU - Boeve, Bradley F.

AU - Knopman, David S.

AU - Petersen, Ronald C.

AU - Parisi, Joseph E.

AU - Jack, Clifford R.

N1 - Funding Information: This study was supported by the NIH Roadmap Multidisciplinary Clinical Research Career Development Award Grant (K12/NICHD)-HD49078, by grants P50 AG16574, U01 AG06786 and R01 AG11378 from the National Institute on Aging, Bethesda MD, NIRG-03-4842 from the Alzheimer's Association, and the generous support of the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation, USA. The authors would like to thank Dennis Hanson from the Biomedical Imaging Resource, Mayo Clinic, for help with the 3D renders. All renders were performed with the Analyze 7.0 software program. The authors would also like to thanks Dr. J. Eric Ahlskog for critical review of this manuscript.

PY - 2008/2

Y1 - 2008/2

N2 - The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.

AB - The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.

KW - Corticobasal degeneration

KW - Dementia

KW - Extrapyramidal

KW - Grey matter

KW - Magnetic resonance imaging

KW - Parkinsonism

KW - Pathology

KW - Progressive supranuclear palsy

KW - White matter

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DO - 10.1016/j.neurobiolaging.2006.09.019

M3 - Article

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AN - SCOPUS:37549002460

SN - 0197-4580

VL - 29

SP - 280

EP - 289

JO - Neurobiology of aging

JF - Neurobiology of aging

IS - 2

ER -

Voxel-based morphometry in autopsy proven PSP and CBD

Abstract

Keywords

ASJC Scopus subject areas

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