Voxel-based morphometry in autopsy proven PSP and CBD

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.

Original languageEnglish (US)
Pages (from-to)280-289
Number of pages10
JournalNeurobiology of aging
Volume29
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Corticobasal degeneration
  • Dementia
  • Extrapyramidal
  • Grey matter
  • Magnetic resonance imaging
  • Parkinsonism
  • Pathology
  • Progressive supranuclear palsy
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Voxel-based morphometry in autopsy proven PSP and CBD'. Together they form a unique fingerprint.

  • Cite this