Von economo neurons in behavioral variant frontotemporal dementia with underlying Alzheimer's disease

Rachel H. Tan, Yue Yang, Heather McCann, Claire Shepherd, Glenda M. Halliday, Jennifer Lynn Whitwell

Research output: Contribution to journalArticle

Abstract

The selective loss of von Economo neurons has been linked to the behavioral deficits in behavioral variant frontotemporal dementia (bvFTD) but whether these neurons are affected in bvFTD patients with underlying Alzheimer's disease (AD) has yet to be established. The present study assesses the von Economo neurons in pathological AD cases clinically diagnosed with either AD or bvFTD. Our results demonstrate no significant loss of von Economo neurons in all pathological AD cases, irrespective of clinical diagnosis or co-existing Lewy body pathology. These results suggest that the behavioral deficits in patients with clinical bvFTD and underlying pathological AD are not driven by the loss of von Economo neurons.

Original languageEnglish (US)
Pages (from-to)963-967
Number of pages5
JournalJournal of Alzheimer's Disease
Volume69
Issue number4
DOIs
StatePublished - Jan 1 2019

Keywords

  • Alzheimer's disease
  • Behavioral variant frontotemporal dementia
  • Lewy body pathology
  • Von Economo neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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