Abstract
The selective loss of von Economo neurons has been linked to the behavioral deficits in behavioral variant frontotemporal dementia (bvFTD) but whether these neurons are affected in bvFTD patients with underlying Alzheimer's disease (AD) has yet to be established. The present study assesses the von Economo neurons in pathological AD cases clinically diagnosed with either AD or bvFTD. Our results demonstrate no significant loss of von Economo neurons in all pathological AD cases, irrespective of clinical diagnosis or co-existing Lewy body pathology. These results suggest that the behavioral deficits in patients with clinical bvFTD and underlying pathological AD are not driven by the loss of von Economo neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 963-967 |
| Number of pages | 5 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 69 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2019 |
Keywords
- Alzheimer's disease
- Behavioral variant frontotemporal dementia
- Lewy body pathology
- Von Economo neurons
ASJC Scopus subject areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health