Volumetric modulated arc therapy for hippocampal-sparing radiotherapy in transformed low-grade glioma: A treatment planning case report

T. Kazda, P. Pospisil, M. Vrzal, O. Sevela, T. Prochazka, R. Jancalek, P. Slampa, Nadia N Laack

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Timing of radiotherapy for low-grade gliomas is still controversial due to concerns of possible adverse late effects. Prevention of possible late cognitive sequelae by hippocampal avoidance has shown promise in phase II trials. A patient with progressive low-grade glioma with gradual dedifferentiation into anaplastic astrocytoma is presented along with description of radiotherapy planning process attempting to spare the hippocampus. To our knowledge, this is the first described case using volumetric modulated arc technique to spare hippocampus during transformed low-grade glioma radiotherapy. Using modern intensity-modulated radiotherapy systems it is possible to selectively spare hippocampus together with other standard organs at risk. For selected patients, an attempt to spare hippocampus can be considered as long as other dose characteristics are not significantly compromised compared to standard treatment plan created without any effort to avoid hippocampus.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalCancer/Radiotherapie
Volume19
Issue number3
DOIs
StatePublished - May 1 2015

Fingerprint

Intensity-Modulated Radiotherapy
Glioma
Hippocampus
Radiotherapy
Organs at Risk
Therapeutics
Astrocytoma

Keywords

  • Astrocytoma
  • Cranial irradiation
  • Hippocampus
  • Neurocognition

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Volumetric modulated arc therapy for hippocampal-sparing radiotherapy in transformed low-grade glioma : A treatment planning case report. / Kazda, T.; Pospisil, P.; Vrzal, M.; Sevela, O.; Prochazka, T.; Jancalek, R.; Slampa, P.; Laack, Nadia N.

In: Cancer/Radiotherapie, Vol. 19, No. 3, 01.05.2015, p. 187-191.

Research output: Contribution to journalArticle

Kazda, T. ; Pospisil, P. ; Vrzal, M. ; Sevela, O. ; Prochazka, T. ; Jancalek, R. ; Slampa, P. ; Laack, Nadia N. / Volumetric modulated arc therapy for hippocampal-sparing radiotherapy in transformed low-grade glioma : A treatment planning case report. In: Cancer/Radiotherapie. 2015 ; Vol. 19, No. 3. pp. 187-191.
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