Volumetric laser endomicroscopy features of dysplasia at the gastric cardia in Barrett's oesophagus: results from an observational cohort study

Arvind J. Trindade, Kara L. Raphael, Sumant Inamdar, Molly Stewart, Joshua Berkowitz, Anil Vegesna, Matthew J. Mckinley, Petros C. Benias, Allon Kahn, Cadman L. Leggett, Calvin Lee, Divyesh V. Sejpal, Arvind Rishi

Research output: Contribution to journalArticle

Abstract

Objective Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's oesophagus (BE) to help identify dysplasia in the oesophagus. VLE criteria exist for oesophageal dysplasia but not for dysplasia in the gastric cardia. The aim of this study was to determine if there are in vivo VLE features that can predict gastric cardia dysplasia in BE. Design This was a single-centre observational cohort study from August 2016 to August 2018. Patients were included if they had BE, were undergoing a VLE exam as standard of care, and had a suspicious target laser marked at the gastric cardia. The following VLE features were correlated to histology to determine if an association existed between histology subtype and VLE feature: wide crypts, irregular surface, one large isolated gland, multiple glands, and complex glands. Results A total of 110 in vivo gastric cardia targets in 77 patients with BE were analysed. The following abnormalities were identified: 61 wide crypts, 34 isolated glands, 16 irregular surfaces, 15 multiple glands, and 11 complex glands. Complex glands were the only VLE feature that correlated to any histology subtype. They were present in 71% of targets with high-grade dysplasia (HGD), T1a cancer or T1b cancer and had a sensitivity, specificity, and accuracy of 71%, 99%, and 85%, respectively. Of the 10 patients with complex glands on VLE and HGD/cancer on histology, 4 had a normal-appearing mucosa (40%) on endoscopy. Conclusion Identification of complex glands on VLE may aid in detection of HGD or early cancer in the gastric cardia in BE. This is particularly important, as dysplasia at the gastric cardia can be difficult to see endoscopically.

Original languageEnglish (US)
Article numbere000340
JournalBMJ Open Gastroenterology
Volume6
Issue number1
DOIs
StatePublished - Oct 1 2019

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Cardia
Barrett Esophagus
Observational Studies
Stomach
Lasers
Cohort Studies
Histology
Neoplasms
Standard of Care
Esophagus
Endoscopy
Stomach Neoplasms
Mucous Membrane
Sensitivity and Specificity

Keywords

  • ablation
  • advanced imaging
  • dysplasia
  • oesophageal cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Volumetric laser endomicroscopy features of dysplasia at the gastric cardia in Barrett's oesophagus : results from an observational cohort study. / Trindade, Arvind J.; Raphael, Kara L.; Inamdar, Sumant; Stewart, Molly; Berkowitz, Joshua; Vegesna, Anil; Mckinley, Matthew J.; Benias, Petros C.; Kahn, Allon; Leggett, Cadman L.; Lee, Calvin; Sejpal, Divyesh V.; Rishi, Arvind.

In: BMJ Open Gastroenterology, Vol. 6, No. 1, e000340, 01.10.2019.

Research output: Contribution to journalArticle

Trindade, AJ, Raphael, KL, Inamdar, S, Stewart, M, Berkowitz, J, Vegesna, A, Mckinley, MJ, Benias, PC, Kahn, A, Leggett, CL, Lee, C, Sejpal, DV & Rishi, A 2019, 'Volumetric laser endomicroscopy features of dysplasia at the gastric cardia in Barrett's oesophagus: results from an observational cohort study', BMJ Open Gastroenterology, vol. 6, no. 1, e000340. https://doi.org/10.1136/bmjgast-2019-000340
Trindade, Arvind J. ; Raphael, Kara L. ; Inamdar, Sumant ; Stewart, Molly ; Berkowitz, Joshua ; Vegesna, Anil ; Mckinley, Matthew J. ; Benias, Petros C. ; Kahn, Allon ; Leggett, Cadman L. ; Lee, Calvin ; Sejpal, Divyesh V. ; Rishi, Arvind. / Volumetric laser endomicroscopy features of dysplasia at the gastric cardia in Barrett's oesophagus : results from an observational cohort study. In: BMJ Open Gastroenterology. 2019 ; Vol. 6, No. 1.
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abstract = "Objective Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's oesophagus (BE) to help identify dysplasia in the oesophagus. VLE criteria exist for oesophageal dysplasia but not for dysplasia in the gastric cardia. The aim of this study was to determine if there are in vivo VLE features that can predict gastric cardia dysplasia in BE. Design This was a single-centre observational cohort study from August 2016 to August 2018. Patients were included if they had BE, were undergoing a VLE exam as standard of care, and had a suspicious target laser marked at the gastric cardia. The following VLE features were correlated to histology to determine if an association existed between histology subtype and VLE feature: wide crypts, irregular surface, one large isolated gland, multiple glands, and complex glands. Results A total of 110 in vivo gastric cardia targets in 77 patients with BE were analysed. The following abnormalities were identified: 61 wide crypts, 34 isolated glands, 16 irregular surfaces, 15 multiple glands, and 11 complex glands. Complex glands were the only VLE feature that correlated to any histology subtype. They were present in 71{\%} of targets with high-grade dysplasia (HGD), T1a cancer or T1b cancer and had a sensitivity, specificity, and accuracy of 71{\%}, 99{\%}, and 85{\%}, respectively. Of the 10 patients with complex glands on VLE and HGD/cancer on histology, 4 had a normal-appearing mucosa (40{\%}) on endoscopy. Conclusion Identification of complex glands on VLE may aid in detection of HGD or early cancer in the gastric cardia in BE. This is particularly important, as dysplasia at the gastric cardia can be difficult to see endoscopically.",
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T1 - Volumetric laser endomicroscopy features of dysplasia at the gastric cardia in Barrett's oesophagus

T2 - results from an observational cohort study

AU - Trindade, Arvind J.

AU - Raphael, Kara L.

AU - Inamdar, Sumant

AU - Stewart, Molly

AU - Berkowitz, Joshua

AU - Vegesna, Anil

AU - Mckinley, Matthew J.

AU - Benias, Petros C.

AU - Kahn, Allon

AU - Leggett, Cadman L.

AU - Lee, Calvin

AU - Sejpal, Divyesh V.

AU - Rishi, Arvind

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objective Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's oesophagus (BE) to help identify dysplasia in the oesophagus. VLE criteria exist for oesophageal dysplasia but not for dysplasia in the gastric cardia. The aim of this study was to determine if there are in vivo VLE features that can predict gastric cardia dysplasia in BE. Design This was a single-centre observational cohort study from August 2016 to August 2018. Patients were included if they had BE, were undergoing a VLE exam as standard of care, and had a suspicious target laser marked at the gastric cardia. The following VLE features were correlated to histology to determine if an association existed between histology subtype and VLE feature: wide crypts, irregular surface, one large isolated gland, multiple glands, and complex glands. Results A total of 110 in vivo gastric cardia targets in 77 patients with BE were analysed. The following abnormalities were identified: 61 wide crypts, 34 isolated glands, 16 irregular surfaces, 15 multiple glands, and 11 complex glands. Complex glands were the only VLE feature that correlated to any histology subtype. They were present in 71% of targets with high-grade dysplasia (HGD), T1a cancer or T1b cancer and had a sensitivity, specificity, and accuracy of 71%, 99%, and 85%, respectively. Of the 10 patients with complex glands on VLE and HGD/cancer on histology, 4 had a normal-appearing mucosa (40%) on endoscopy. Conclusion Identification of complex glands on VLE may aid in detection of HGD or early cancer in the gastric cardia in BE. This is particularly important, as dysplasia at the gastric cardia can be difficult to see endoscopically.

AB - Objective Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's oesophagus (BE) to help identify dysplasia in the oesophagus. VLE criteria exist for oesophageal dysplasia but not for dysplasia in the gastric cardia. The aim of this study was to determine if there are in vivo VLE features that can predict gastric cardia dysplasia in BE. Design This was a single-centre observational cohort study from August 2016 to August 2018. Patients were included if they had BE, were undergoing a VLE exam as standard of care, and had a suspicious target laser marked at the gastric cardia. The following VLE features were correlated to histology to determine if an association existed between histology subtype and VLE feature: wide crypts, irregular surface, one large isolated gland, multiple glands, and complex glands. Results A total of 110 in vivo gastric cardia targets in 77 patients with BE were analysed. The following abnormalities were identified: 61 wide crypts, 34 isolated glands, 16 irregular surfaces, 15 multiple glands, and 11 complex glands. Complex glands were the only VLE feature that correlated to any histology subtype. They were present in 71% of targets with high-grade dysplasia (HGD), T1a cancer or T1b cancer and had a sensitivity, specificity, and accuracy of 71%, 99%, and 85%, respectively. Of the 10 patients with complex glands on VLE and HGD/cancer on histology, 4 had a normal-appearing mucosa (40%) on endoscopy. Conclusion Identification of complex glands on VLE may aid in detection of HGD or early cancer in the gastric cardia in BE. This is particularly important, as dysplasia at the gastric cardia can be difficult to see endoscopically.

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