TY - JOUR
T1 - Volume Progression and Imaging Classification of Polycystic Liver in Early Autosomal Dominant Polycystic Kidney Disease
AU - CRISP and HALT PKD Consortium
AU - Bae, Kyongtae T.
AU - Tao, Cheng
AU - Feldman, Robert
AU - Yu, Alan S.L.
AU - Torres, Vicente E.
AU - Perrone, Ronald D.
AU - Chapman, Arlene B.
AU - Brosnahan, Godela
AU - Steinman, Theodore I.
AU - Braun, William E.
AU - Mrug, Michal
AU - Bennett, William M.
AU - Harris, Peter C.
AU - Srivastava, Avantika
AU - Landsittel, Douglas P.
AU - Abebe, Kaleab Z.
N1 - Funding Information:
This work was supported by National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health grants DK056943, DK056956, DK056957, DK056961, and R01 DK113111. This study was also supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases; PKD grant DK106912; Mayo Translational PKD Center grant DK090728; Emory University; National Center for Research Resources grant RR000039; Kansas University Medical Center grants RR033179, RR23940, and TR000001; National Center for Advancing Translational Sciences grants RR025008 and TR000454; Mayo College of Medicine grants RR00585, RR024150, and TR000135; University of Alabama at Birmingham grants RR000032, RR025777, TR000165, and TR001417; and University of Pittsburgh School of Medicine grants RR024153 and TR000005.
Publisher Copyright:
© 2022 by the American Society of Nephrology.
PY - 2022/3
Y1 - 2022/3
N2 - Background and objectives The progression of polycystic liver disease is not well understood. The purpose of the study is to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient’s age, height-adjusted liver cystic volume, and height-adjusted liver volume. Design, setting, participants, & measurements Prospective longitudinal magnetic resonance images from 670 patients with early autosomal dominant polycystic kidney disease for up to 14 years of follow-up were evaluated to measure height-adjusted liver cystic volume and height-adjusted liver volume. Among them, 245 patients with liver cyst volume >50 ml at baseline were included in the longitudinal analysis. Linear mixed models on log-transformed height-adjusted liver cystic volume and height-adjusted liver volume were fitted to approximate mean annual rate of change for each outcome. The association of sex, body mass index, genotype, baseline height-adjusted total kidney volume, and Mayo imaging class was assessed. We calculated height-adjusted liver cystic volume ranges for each specific age and divided them into five classes on the basis of annual percentage increase in height-adjusted liver cystic volume. Results The mean annual growth rate of height-adjusted liver cystic volume was 12% (95% confidence interval, 11.1% to 13.1%; P<0.001), whereas that for height-adjusted liver volume was 2% (95% confidence interval, 1.9% to 2.6%; P<0.001). Women had higher baseline height-adjusted liver cystic volume than men, but men had higher height-adjusted liver cystic volume growth rate than women by 2% (95% confidence interval, 0.4% to 4.5%; P=0.02). Whereas the height-adjusted liver cystic volume growth rate decreased in women after menopause, no decrease was observed in men at any age. Body mass index, genotype, and baseline height-adjusted total kidney volume were not associated with the growth rate of height-adjusted liver cystic volume or height-adjusted liver volume. According to the height-adjusted liver cystic volume growth rate, patients were classified into five classes (number of women, men in each class): A (24, six); B (44, 13); C (43, 48); D (28, 17); and E (13, nine). Conclusions Compared with height-adjusted liver volume, the use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease. Similar to the Mayo imaging classification for the kidney, the progression of polycystic liver disease may be categorized on the basis of patient’s age and height-adjusted liver cystic volume.
AB - Background and objectives The progression of polycystic liver disease is not well understood. The purpose of the study is to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient’s age, height-adjusted liver cystic volume, and height-adjusted liver volume. Design, setting, participants, & measurements Prospective longitudinal magnetic resonance images from 670 patients with early autosomal dominant polycystic kidney disease for up to 14 years of follow-up were evaluated to measure height-adjusted liver cystic volume and height-adjusted liver volume. Among them, 245 patients with liver cyst volume >50 ml at baseline were included in the longitudinal analysis. Linear mixed models on log-transformed height-adjusted liver cystic volume and height-adjusted liver volume were fitted to approximate mean annual rate of change for each outcome. The association of sex, body mass index, genotype, baseline height-adjusted total kidney volume, and Mayo imaging class was assessed. We calculated height-adjusted liver cystic volume ranges for each specific age and divided them into five classes on the basis of annual percentage increase in height-adjusted liver cystic volume. Results The mean annual growth rate of height-adjusted liver cystic volume was 12% (95% confidence interval, 11.1% to 13.1%; P<0.001), whereas that for height-adjusted liver volume was 2% (95% confidence interval, 1.9% to 2.6%; P<0.001). Women had higher baseline height-adjusted liver cystic volume than men, but men had higher height-adjusted liver cystic volume growth rate than women by 2% (95% confidence interval, 0.4% to 4.5%; P=0.02). Whereas the height-adjusted liver cystic volume growth rate decreased in women after menopause, no decrease was observed in men at any age. Body mass index, genotype, and baseline height-adjusted total kidney volume were not associated with the growth rate of height-adjusted liver cystic volume or height-adjusted liver volume. According to the height-adjusted liver cystic volume growth rate, patients were classified into five classes (number of women, men in each class): A (24, six); B (44, 13); C (43, 48); D (28, 17); and E (13, nine). Conclusions Compared with height-adjusted liver volume, the use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease. Similar to the Mayo imaging classification for the kidney, the progression of polycystic liver disease may be categorized on the basis of patient’s age and height-adjusted liver cystic volume.
KW - ADPKD
KW - Diagnostic imaging
KW - Disease progression
KW - Genetic renal disease
KW - Kidney volume
KW - Liver
KW - Liver cysts
KW - Polycystic kidney disease
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U2 - 10.2215/CJN.08660621
DO - 10.2215/CJN.08660621
M3 - Article
C2 - 35217526
AN - SCOPUS:85125964928
SN - 1555-9041
VL - 17
SP - 374
EP - 384
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 3
ER -