Vitreoretinal lymphoma versus uveitis: Cytokine profile and correlations

Juline N. Caraballo, Melissa R. Snyder, Patrick B. Johnston, Brian P. O Neill, Harish Raja, Joseph G. Balsanek, Brian E. Peters, Jose S. Pulido

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: To compare the cytokine spectrum of vitreoretinal lymphoma to uveitis and correlate cytokine concentrations with disease activity. Methods: Retrospective case series of 10 patients with vitreoretinal lymphoma and 7 patients with uveitis. Aqueous humor concentration of IFN-γ, TNF-α, TNF-β, IL-1ra, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, MCP-1, G-CSF, GM-CSF, and VEGF-A was determined using a bead-based assay (Luminex). Variance between groups, correlation coefficients, and longitudinal behavior of cytokines were analyzed. Results: No statistically significant difference in cytokines was found when comparing groups. IL-10 was positively correlated with IL-6 and MCP-1. IL-6 was positively correlated with G-CSF, IL-1ra, IL-8, and IL-10. A relationship between concentration of any cytokine, aside from IL-10, and disease activity was not found. Conclusion: IL-10 and IL-6 are good immunologic markers to be used as complementary diagnostic tools. IL-10 is the only IL that could be used for monitoring purposes.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalOcular Immunology and Inflammation
Volume22
Issue number1
DOIs
StatePublished - Feb 1 2014

Keywords

  • Cytokines
  • Interleukin-10
  • Interleukin-6
  • Uveitis
  • Vitreoretinal lymphoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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