TY - JOUR
T1 - Vitreoretinal lymphoma versus uveitis
T2 - Cytokine profile and correlations
AU - Caraballo, Juline N.
AU - Snyder, Melissa R.
AU - Johnston, Patrick B.
AU - O Neill, Brian P.
AU - Raja, Harish
AU - Balsanek, Joseph G.
AU - Peters, Brian E.
AU - Pulido, Jose S.
N1 - Funding Information:
This study was performed at the Mayo Clinic, Rochester, MN and was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, NY, and from the Mayo Cancer Center. The authors have no proprietary interests in this work.
PY - 2014/2
Y1 - 2014/2
N2 - Purpose: To compare the cytokine spectrum of vitreoretinal lymphoma to uveitis and correlate cytokine concentrations with disease activity. Methods: Retrospective case series of 10 patients with vitreoretinal lymphoma and 7 patients with uveitis. Aqueous humor concentration of IFN-γ, TNF-α, TNF-β, IL-1ra, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, MCP-1, G-CSF, GM-CSF, and VEGF-A was determined using a bead-based assay (Luminex). Variance between groups, correlation coefficients, and longitudinal behavior of cytokines were analyzed. Results: No statistically significant difference in cytokines was found when comparing groups. IL-10 was positively correlated with IL-6 and MCP-1. IL-6 was positively correlated with G-CSF, IL-1ra, IL-8, and IL-10. A relationship between concentration of any cytokine, aside from IL-10, and disease activity was not found. Conclusion: IL-10 and IL-6 are good immunologic markers to be used as complementary diagnostic tools. IL-10 is the only IL that could be used for monitoring purposes.
AB - Purpose: To compare the cytokine spectrum of vitreoretinal lymphoma to uveitis and correlate cytokine concentrations with disease activity. Methods: Retrospective case series of 10 patients with vitreoretinal lymphoma and 7 patients with uveitis. Aqueous humor concentration of IFN-γ, TNF-α, TNF-β, IL-1ra, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, MCP-1, G-CSF, GM-CSF, and VEGF-A was determined using a bead-based assay (Luminex). Variance between groups, correlation coefficients, and longitudinal behavior of cytokines were analyzed. Results: No statistically significant difference in cytokines was found when comparing groups. IL-10 was positively correlated with IL-6 and MCP-1. IL-6 was positively correlated with G-CSF, IL-1ra, IL-8, and IL-10. A relationship between concentration of any cytokine, aside from IL-10, and disease activity was not found. Conclusion: IL-10 and IL-6 are good immunologic markers to be used as complementary diagnostic tools. IL-10 is the only IL that could be used for monitoring purposes.
KW - Cytokines
KW - Interleukin-10
KW - Interleukin-6
KW - Uveitis
KW - Vitreoretinal lymphoma
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U2 - 10.3109/09273948.2012.752507
DO - 10.3109/09273948.2012.752507
M3 - Article
C2 - 24490677
AN - SCOPUS:84893470150
SN - 0927-3948
VL - 22
SP - 34
EP - 41
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 1
ER -