Vitamins and prostate cancer risk

Krishna Vanaja Donkena, R. Jeffrey Karnes, Charles Y.F. Young

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Prostate cancer (PC) is the second most common cancer in men worldwide. Its prevention and treatment remain a challenge to clinicians. Here we review the relationship of vitamins to PC risk. Many vitamins and related chemicals, including vitamin A, retinoids, several B vitamins, vitamin C, vitamin D and vitamin E have shown their anticancer activities as anti-oxidants, activators of transcription factors or factors influencing epigenetic events. Although laboratory tests including the use of animal models showed these vitamins may have anti-PC properties, whether they can effectively prevent the development and/or progression of PC in humans remains to be intensively studied subjects. This review will provide up-to-date information regarding the recent outcomes of laboratory, epidemiology and/or clinical trials on the effects of vitamins on PC prevention and/or treatment.

Original languageEnglish (US)
Pages (from-to)1762-1783
Number of pages22
JournalMolecules
Volume15
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Folic acid
  • Prostate cancer
  • Retinoids
  • SNP
  • Vitamins A, B, C, D, and E

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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