Vitamin E and evening primrose oil for management of cyclical mastalgia: A randomized pilot study

Sandhya Pruthi, Dietlind L. Wahner-Roedler, Carolyn J. Torkelson, Stephen S. Cha, Lori S. Thicke, Jennifer H. Hazelton, Brent A Bauer

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the effectiveness of vitamin E, evening primrose oil (EPO), and the combination of vitamin E and EPO for pain control in women with cyclical mastalgia. PROCEDURE: A double-blind, randomized, placebo-controlled trial was conducted at two U.S. academic medical centers. Eighty-five women with premenstrual cyclical breast discomfort were enrolled. Participants were randomly assigned to one of four six-month oral treatments: vitamin E (1,200 IU/day), EPO (3,000 mg/day), vitamin E (1,200 IU/day) plus EPO (3,000 mg/day), or double placebo. The primary outcome measure was change in breast pain, measured by the modified McGill Pain Questionnaire at enrollment and at six months. RESULTS: Forty-one patients completed the study. Intent-to-treat analysis (pretesting and post testing) showed a difference in worst-pain improvement with the treatments EPO (p=0.005), vitamin E (p=0.04), and EPO plus vitamin E (p=0.05), but no difference with placebo (p=0.93). Results from two-sample t-test showed a nonsignificant decrease in cyclical mastalgia individually for the three treatment groups compared with the placebo group (EPO, p=0.18; vitamin E, p=0.10; and EPO plus vitamin E, p=0.16). The data were also analyzed with the separation test by Aickin, which showed a trend toward a reduction of cyclical mastalgia with vitamin E and EPO individually and in combination. CONCLUSION: Daily doses of 1,200 IU vitamin E, 3,000 mg EPO, or vitamin E and EPO in combination at these same dosages taken for six months may decrease the severity of cyclical mastalgia.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalAlternative Medicine Review
Volume15
Issue number1
StatePublished - Apr 2010

Fingerprint

Mastodynia
Vitamin E
Placebos
Efamol
Pain
Pain Measurement
Breast
Therapeutics

Keywords

  • Breast
  • Essential fatty acids
  • Evening primrose
  • GLA
  • Mastalgia
  • Menstrual cycle
  • PMS
  • Tocopherol
  • Vitamin E

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Pruthi, S., Wahner-Roedler, D. L., Torkelson, C. J., Cha, S. S., Thicke, L. S., Hazelton, J. H., & Bauer, B. A. (2010). Vitamin E and evening primrose oil for management of cyclical mastalgia: A randomized pilot study. Alternative Medicine Review, 15(1), 59-67.

Vitamin E and evening primrose oil for management of cyclical mastalgia : A randomized pilot study. / Pruthi, Sandhya; Wahner-Roedler, Dietlind L.; Torkelson, Carolyn J.; Cha, Stephen S.; Thicke, Lori S.; Hazelton, Jennifer H.; Bauer, Brent A.

In: Alternative Medicine Review, Vol. 15, No. 1, 04.2010, p. 59-67.

Research output: Contribution to journalArticle

Pruthi, S, Wahner-Roedler, DL, Torkelson, CJ, Cha, SS, Thicke, LS, Hazelton, JH & Bauer, BA 2010, 'Vitamin E and evening primrose oil for management of cyclical mastalgia: A randomized pilot study', Alternative Medicine Review, vol. 15, no. 1, pp. 59-67.
Pruthi S, Wahner-Roedler DL, Torkelson CJ, Cha SS, Thicke LS, Hazelton JH et al. Vitamin E and evening primrose oil for management of cyclical mastalgia: A randomized pilot study. Alternative Medicine Review. 2010 Apr;15(1):59-67.
Pruthi, Sandhya ; Wahner-Roedler, Dietlind L. ; Torkelson, Carolyn J. ; Cha, Stephen S. ; Thicke, Lori S. ; Hazelton, Jennifer H. ; Bauer, Brent A. / Vitamin E and evening primrose oil for management of cyclical mastalgia : A randomized pilot study. In: Alternative Medicine Review. 2010 ; Vol. 15, No. 1. pp. 59-67.
@article{614c5ce5fda645eea837ad26a4de493b,
title = "Vitamin E and evening primrose oil for management of cyclical mastalgia: A randomized pilot study",
abstract = "OBJECTIVE: To evaluate the effectiveness of vitamin E, evening primrose oil (EPO), and the combination of vitamin E and EPO for pain control in women with cyclical mastalgia. PROCEDURE: A double-blind, randomized, placebo-controlled trial was conducted at two U.S. academic medical centers. Eighty-five women with premenstrual cyclical breast discomfort were enrolled. Participants were randomly assigned to one of four six-month oral treatments: vitamin E (1,200 IU/day), EPO (3,000 mg/day), vitamin E (1,200 IU/day) plus EPO (3,000 mg/day), or double placebo. The primary outcome measure was change in breast pain, measured by the modified McGill Pain Questionnaire at enrollment and at six months. RESULTS: Forty-one patients completed the study. Intent-to-treat analysis (pretesting and post testing) showed a difference in worst-pain improvement with the treatments EPO (p=0.005), vitamin E (p=0.04), and EPO plus vitamin E (p=0.05), but no difference with placebo (p=0.93). Results from two-sample t-test showed a nonsignificant decrease in cyclical mastalgia individually for the three treatment groups compared with the placebo group (EPO, p=0.18; vitamin E, p=0.10; and EPO plus vitamin E, p=0.16). The data were also analyzed with the separation test by Aickin, which showed a trend toward a reduction of cyclical mastalgia with vitamin E and EPO individually and in combination. CONCLUSION: Daily doses of 1,200 IU vitamin E, 3,000 mg EPO, or vitamin E and EPO in combination at these same dosages taken for six months may decrease the severity of cyclical mastalgia.",
keywords = "Breast, Essential fatty acids, Evening primrose, GLA, Mastalgia, Menstrual cycle, PMS, Tocopherol, Vitamin E",
author = "Sandhya Pruthi and Wahner-Roedler, {Dietlind L.} and Torkelson, {Carolyn J.} and Cha, {Stephen S.} and Thicke, {Lori S.} and Hazelton, {Jennifer H.} and Bauer, {Brent A}",
year = "2010",
month = "4",
language = "English (US)",
volume = "15",
pages = "59--67",
journal = "Alternative Medicine Review",
issn = "1089-5159",
publisher = "Thorne Research Inc.",
number = "1",

}

TY - JOUR

T1 - Vitamin E and evening primrose oil for management of cyclical mastalgia

T2 - A randomized pilot study

AU - Pruthi, Sandhya

AU - Wahner-Roedler, Dietlind L.

AU - Torkelson, Carolyn J.

AU - Cha, Stephen S.

AU - Thicke, Lori S.

AU - Hazelton, Jennifer H.

AU - Bauer, Brent A

PY - 2010/4

Y1 - 2010/4

N2 - OBJECTIVE: To evaluate the effectiveness of vitamin E, evening primrose oil (EPO), and the combination of vitamin E and EPO for pain control in women with cyclical mastalgia. PROCEDURE: A double-blind, randomized, placebo-controlled trial was conducted at two U.S. academic medical centers. Eighty-five women with premenstrual cyclical breast discomfort were enrolled. Participants were randomly assigned to one of four six-month oral treatments: vitamin E (1,200 IU/day), EPO (3,000 mg/day), vitamin E (1,200 IU/day) plus EPO (3,000 mg/day), or double placebo. The primary outcome measure was change in breast pain, measured by the modified McGill Pain Questionnaire at enrollment and at six months. RESULTS: Forty-one patients completed the study. Intent-to-treat analysis (pretesting and post testing) showed a difference in worst-pain improvement with the treatments EPO (p=0.005), vitamin E (p=0.04), and EPO plus vitamin E (p=0.05), but no difference with placebo (p=0.93). Results from two-sample t-test showed a nonsignificant decrease in cyclical mastalgia individually for the three treatment groups compared with the placebo group (EPO, p=0.18; vitamin E, p=0.10; and EPO plus vitamin E, p=0.16). The data were also analyzed with the separation test by Aickin, which showed a trend toward a reduction of cyclical mastalgia with vitamin E and EPO individually and in combination. CONCLUSION: Daily doses of 1,200 IU vitamin E, 3,000 mg EPO, or vitamin E and EPO in combination at these same dosages taken for six months may decrease the severity of cyclical mastalgia.

AB - OBJECTIVE: To evaluate the effectiveness of vitamin E, evening primrose oil (EPO), and the combination of vitamin E and EPO for pain control in women with cyclical mastalgia. PROCEDURE: A double-blind, randomized, placebo-controlled trial was conducted at two U.S. academic medical centers. Eighty-five women with premenstrual cyclical breast discomfort were enrolled. Participants were randomly assigned to one of four six-month oral treatments: vitamin E (1,200 IU/day), EPO (3,000 mg/day), vitamin E (1,200 IU/day) plus EPO (3,000 mg/day), or double placebo. The primary outcome measure was change in breast pain, measured by the modified McGill Pain Questionnaire at enrollment and at six months. RESULTS: Forty-one patients completed the study. Intent-to-treat analysis (pretesting and post testing) showed a difference in worst-pain improvement with the treatments EPO (p=0.005), vitamin E (p=0.04), and EPO plus vitamin E (p=0.05), but no difference with placebo (p=0.93). Results from two-sample t-test showed a nonsignificant decrease in cyclical mastalgia individually for the three treatment groups compared with the placebo group (EPO, p=0.18; vitamin E, p=0.10; and EPO plus vitamin E, p=0.16). The data were also analyzed with the separation test by Aickin, which showed a trend toward a reduction of cyclical mastalgia with vitamin E and EPO individually and in combination. CONCLUSION: Daily doses of 1,200 IU vitamin E, 3,000 mg EPO, or vitamin E and EPO in combination at these same dosages taken for six months may decrease the severity of cyclical mastalgia.

KW - Breast

KW - Essential fatty acids

KW - Evening primrose

KW - GLA

KW - Mastalgia

KW - Menstrual cycle

KW - PMS

KW - Tocopherol

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=77952308495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952308495&partnerID=8YFLogxK

M3 - Article

C2 - 20359269

AN - SCOPUS:77952308495

VL - 15

SP - 59

EP - 67

JO - Alternative Medicine Review

JF - Alternative Medicine Review

SN - 1089-5159

IS - 1

ER -