Vitamin D effect on umbilical cord blood characteristics: A comparison between African Americans and Caucasians

Lamis K. Eldjerou, Christopher R. Cogle, Emma H. Rosenau, Xiaomin Lu, Clay A. Bennett, Michele W. Sugrue, Jonathan Hoyne, Amy Lambert, Lindsay Ashley, Kathleen Sazama, Gary Fields, John R. Wingard, Abba Zubair

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND Umbilical cord blood (UCB) units collected from African Americans (AAs) have lower total nucleated cell (TNC) and CD34+ cell counts and are more likely to disqualify for banking compared to other ethnic groups. Furthermore, AAs have higher prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency. Given the importance of 25(OH)D in hematopoiesis, we examined the racial differences in UCB unit 25(OH)D content and its correlation with UCB cellular characteristics. STUDY DESIGN AND METHODS A total of 119 UCB units that did not meet the TNC count banking criteria were analyzed. Fifty-one UCB units were collected from AA mothers and 68 from Caucasian mothers. We analyzed UCB volume, hematocrit (Hct), TNCs, mononuclear cells (MNCs), CD34+ cells, plasma 25(OH)D concentration, and progenitor clonogenic capacity measured by colony-forming cell (CFC) assay. RESULTS Compared to Caucasians, AAs had significantly lower UCB 25(OH)D levels (p<0.0001), TNCs (p=0.002), MNCs (p=0.026), and CD34+ cells (p=0.026). Severe deficiency (25(OH)D<10 ng/mL) was only detected in AAs. No difference in median CFC count/10,000 MNCs was detected between AAs and Caucasians. Independent of race, a significant association was detected between 25(OH)D level and TNCs (r=0.193 p=0.035) and Hct (r=0.196 p=0.033). CONCLUSION These results indicate the importance of 25(OH)D level as a racially independent predictor of UCB cellular characteristics and support further investigation of bioactive vitamin D and other predictors of hematopoiesis on cord blood quality.

Original languageEnglish (US)
Pages (from-to)1766-1771
Number of pages6
JournalTransfusion
Volume55
Issue number7
DOIs
StatePublished - Jul 1 2015

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Fetal Blood
Vitamin D
African Americans
Cell Count
Hematopoiesis
Hematocrit
Mothers
Plasma Cells
Blood Volume
Ethnic Groups

ASJC Scopus subject areas

  • Hematology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Eldjerou, L. K., Cogle, C. R., Rosenau, E. H., Lu, X., Bennett, C. A., Sugrue, M. W., ... Zubair, A. (2015). Vitamin D effect on umbilical cord blood characteristics: A comparison between African Americans and Caucasians. Transfusion, 55(7), 1766-1771. https://doi.org/10.1111/trf.13124

Vitamin D effect on umbilical cord blood characteristics : A comparison between African Americans and Caucasians. / Eldjerou, Lamis K.; Cogle, Christopher R.; Rosenau, Emma H.; Lu, Xiaomin; Bennett, Clay A.; Sugrue, Michele W.; Hoyne, Jonathan; Lambert, Amy; Ashley, Lindsay; Sazama, Kathleen; Fields, Gary; Wingard, John R.; Zubair, Abba.

In: Transfusion, Vol. 55, No. 7, 01.07.2015, p. 1766-1771.

Research output: Contribution to journalArticle

Eldjerou, LK, Cogle, CR, Rosenau, EH, Lu, X, Bennett, CA, Sugrue, MW, Hoyne, J, Lambert, A, Ashley, L, Sazama, K, Fields, G, Wingard, JR & Zubair, A 2015, 'Vitamin D effect on umbilical cord blood characteristics: A comparison between African Americans and Caucasians', Transfusion, vol. 55, no. 7, pp. 1766-1771. https://doi.org/10.1111/trf.13124
Eldjerou, Lamis K. ; Cogle, Christopher R. ; Rosenau, Emma H. ; Lu, Xiaomin ; Bennett, Clay A. ; Sugrue, Michele W. ; Hoyne, Jonathan ; Lambert, Amy ; Ashley, Lindsay ; Sazama, Kathleen ; Fields, Gary ; Wingard, John R. ; Zubair, Abba. / Vitamin D effect on umbilical cord blood characteristics : A comparison between African Americans and Caucasians. In: Transfusion. 2015 ; Vol. 55, No. 7. pp. 1766-1771.
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abstract = "BACKGROUND Umbilical cord blood (UCB) units collected from African Americans (AAs) have lower total nucleated cell (TNC) and CD34+ cell counts and are more likely to disqualify for banking compared to other ethnic groups. Furthermore, AAs have higher prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency. Given the importance of 25(OH)D in hematopoiesis, we examined the racial differences in UCB unit 25(OH)D content and its correlation with UCB cellular characteristics. STUDY DESIGN AND METHODS A total of 119 UCB units that did not meet the TNC count banking criteria were analyzed. Fifty-one UCB units were collected from AA mothers and 68 from Caucasian mothers. We analyzed UCB volume, hematocrit (Hct), TNCs, mononuclear cells (MNCs), CD34+ cells, plasma 25(OH)D concentration, and progenitor clonogenic capacity measured by colony-forming cell (CFC) assay. RESULTS Compared to Caucasians, AAs had significantly lower UCB 25(OH)D levels (p<0.0001), TNCs (p=0.002), MNCs (p=0.026), and CD34+ cells (p=0.026). Severe deficiency (25(OH)D<10 ng/mL) was only detected in AAs. No difference in median CFC count/10,000 MNCs was detected between AAs and Caucasians. Independent of race, a significant association was detected between 25(OH)D level and TNCs (r=0.193 p=0.035) and Hct (r=0.196 p=0.033). CONCLUSION These results indicate the importance of 25(OH)D level as a racially independent predictor of UCB cellular characteristics and support further investigation of bioactive vitamin D and other predictors of hematopoiesis on cord blood quality.",
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T1 - Vitamin D effect on umbilical cord blood characteristics

T2 - A comparison between African Americans and Caucasians

AU - Eldjerou, Lamis K.

AU - Cogle, Christopher R.

AU - Rosenau, Emma H.

AU - Lu, Xiaomin

AU - Bennett, Clay A.

AU - Sugrue, Michele W.

AU - Hoyne, Jonathan

AU - Lambert, Amy

AU - Ashley, Lindsay

AU - Sazama, Kathleen

AU - Fields, Gary

AU - Wingard, John R.

AU - Zubair, Abba

PY - 2015/7/1

Y1 - 2015/7/1

N2 - BACKGROUND Umbilical cord blood (UCB) units collected from African Americans (AAs) have lower total nucleated cell (TNC) and CD34+ cell counts and are more likely to disqualify for banking compared to other ethnic groups. Furthermore, AAs have higher prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency. Given the importance of 25(OH)D in hematopoiesis, we examined the racial differences in UCB unit 25(OH)D content and its correlation with UCB cellular characteristics. STUDY DESIGN AND METHODS A total of 119 UCB units that did not meet the TNC count banking criteria were analyzed. Fifty-one UCB units were collected from AA mothers and 68 from Caucasian mothers. We analyzed UCB volume, hematocrit (Hct), TNCs, mononuclear cells (MNCs), CD34+ cells, plasma 25(OH)D concentration, and progenitor clonogenic capacity measured by colony-forming cell (CFC) assay. RESULTS Compared to Caucasians, AAs had significantly lower UCB 25(OH)D levels (p<0.0001), TNCs (p=0.002), MNCs (p=0.026), and CD34+ cells (p=0.026). Severe deficiency (25(OH)D<10 ng/mL) was only detected in AAs. No difference in median CFC count/10,000 MNCs was detected between AAs and Caucasians. Independent of race, a significant association was detected between 25(OH)D level and TNCs (r=0.193 p=0.035) and Hct (r=0.196 p=0.033). CONCLUSION These results indicate the importance of 25(OH)D level as a racially independent predictor of UCB cellular characteristics and support further investigation of bioactive vitamin D and other predictors of hematopoiesis on cord blood quality.

AB - BACKGROUND Umbilical cord blood (UCB) units collected from African Americans (AAs) have lower total nucleated cell (TNC) and CD34+ cell counts and are more likely to disqualify for banking compared to other ethnic groups. Furthermore, AAs have higher prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency. Given the importance of 25(OH)D in hematopoiesis, we examined the racial differences in UCB unit 25(OH)D content and its correlation with UCB cellular characteristics. STUDY DESIGN AND METHODS A total of 119 UCB units that did not meet the TNC count banking criteria were analyzed. Fifty-one UCB units were collected from AA mothers and 68 from Caucasian mothers. We analyzed UCB volume, hematocrit (Hct), TNCs, mononuclear cells (MNCs), CD34+ cells, plasma 25(OH)D concentration, and progenitor clonogenic capacity measured by colony-forming cell (CFC) assay. RESULTS Compared to Caucasians, AAs had significantly lower UCB 25(OH)D levels (p<0.0001), TNCs (p=0.002), MNCs (p=0.026), and CD34+ cells (p=0.026). Severe deficiency (25(OH)D<10 ng/mL) was only detected in AAs. No difference in median CFC count/10,000 MNCs was detected between AAs and Caucasians. Independent of race, a significant association was detected between 25(OH)D level and TNCs (r=0.193 p=0.035) and Hct (r=0.196 p=0.033). CONCLUSION These results indicate the importance of 25(OH)D level as a racially independent predictor of UCB cellular characteristics and support further investigation of bioactive vitamin D and other predictors of hematopoiesis on cord blood quality.

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