Vitamin D and the Kidney

Peter Tebben; Rajiv Kumar

doi:10.1016/B978-0-12-809965-0.00026-4

Vitamin D and the Kidney

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The kidney plays a vital role in the conservation of calcium and phosphorus. The kidney responds to various hormones including 1α,25-dihydroxyvitamin D (1α,25(OH)₂D) by increasing or decreasing the efficiency of calcium and phosphorus reabsorption along the nephron. Important proteins that significantly change the efficiency of calcium and phosphorus transport are localized along the distal and proximal nephron. The kidney expresses the vitamin D receptor (VDR) and is the site of synthesis of 1α,25(OH)₂D by the 25-hydroxyvitamin D (25(OH)D)-1α-hydroxylase, and the site of synthesis of 24R,25-dihydroxyvitamin D by the 25(OH)D-24-hydroxylase. Elements of the calcium transport systems including calbindin D_28K, calbindin D_9K, the epithelial calcium channel, and the plasma membrane calcium pump all localize to the distal portion of the nephron and are regulated by 1α,25(OH)₂D₃ and its receptor, the VDR.

Original language	English (US)
Title of host publication	Biochemistry, Physiology and Diagnostics
Publisher	Elsevier Inc.
Pages	437-459
Number of pages	23
Volume	1
ISBN (Electronic)	9780128099667
ISBN (Print)	9780128099650
DOIs	https://doi.org/10.1016/B978-0-12-809965-0.00026-4
State	Published - Dec 18 2017

Keywords

1α,25-dihydroxyvitamin D
24R,25-dihydroxyvitamin D
25-Hydroxyvitamin D-1α-hydroxylase
Calbindin D
Calbindin D
Cyp24A1
Cyp27B1
PMCa
TRPV5
TRPV6

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1016/B978-0-12-809965-0.00026-4

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abstract = "The kidney plays a vital role in the conservation of calcium and phosphorus. The kidney responds to various hormones including 1α,25-dihydroxyvitamin D (1α,25(OH)2D) by increasing or decreasing the efficiency of calcium and phosphorus reabsorption along the nephron. Important proteins that significantly change the efficiency of calcium and phosphorus transport are localized along the distal and proximal nephron. The kidney expresses the vitamin D receptor (VDR) and is the site of synthesis of 1α,25(OH)2D by the 25-hydroxyvitamin D (25(OH)D)-1α-hydroxylase, and the site of synthesis of 24R,25-dihydroxyvitamin D by the 25(OH)D-24-hydroxylase. Elements of the calcium transport systems including calbindin D28K, calbindin D9K, the epithelial calcium channel, and the plasma membrane calcium pump all localize to the distal portion of the nephron and are regulated by 1α,25(OH)2D3 and its receptor, the VDR.",

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KW - 1α,25-dihydroxyvitamin D

KW - 24R,25-dihydroxyvitamin D

KW - 25-Hydroxyvitamin D-1α-hydroxylase

KW - Calbindin D

KW - Cyp24A1

KW - Cyp27B1

KW - PMCa

KW - TRPV5

KW - TRPV6

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PB - Elsevier Inc.

ER -

Vitamin D and the Kidney

Abstract

Keywords

ASJC Scopus subject areas

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