Vitamin D and the Kidney

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The kidney plays a vital role in the conservation of calcium and phosphorus. The kidney responds to various hormones including 1α,25-dihydroxyvitamin D (1α,25(OH)2D) by increasing or decreasing the efficiency of calcium and phosphorus reabsorption along the nephron. Important proteins that significantly change the efficiency of calcium and phosphorus transport are localized along the distal and proximal nephron. The kidney expresses the vitamin D receptor (VDR) and is the site of synthesis of 1α,25(OH)2D by the 25-hydroxyvitamin D (25(OH)D)-1α-hydroxylase, and the site of synthesis of 24R,25-dihydroxyvitamin D by the 25(OH)D-24-hydroxylase. Elements of the calcium transport systems including calbindin D28K, calbindin D9K, the epithelial calcium channel, and the plasma membrane calcium pump all localize to the distal portion of the nephron and are regulated by 1α,25(OH)2D3 and its receptor, the VDR.

Original languageEnglish (US)
Title of host publicationBiochemistry, Physiology and Diagnostics
PublisherElsevier Inc.
Pages437-459
Number of pages23
Volume1
ISBN (Electronic)9780128099667
ISBN (Print)9780128099650
DOIs
StatePublished - Dec 18 2017

Keywords

  • 1α,25-dihydroxyvitamin D
  • 24R,25-dihydroxyvitamin D
  • 25-Hydroxyvitamin D-1α-hydroxylase
  • Calbindin D
  • Calbindin D
  • Cyp24A1
  • Cyp27B1
  • PMCa
  • TRPV5
  • TRPV6

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Tebben, P., & Kumar, R. (2017). Vitamin D and the Kidney. In Biochemistry, Physiology and Diagnostics (Vol. 1, pp. 437-459). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809965-0.00026-4