Visualization of nonfunctioning adrenal adenomas with iodocholesterol: possible relationship to subcellular distribution of tracer

R. A. Rizza, H. W. Wahner, T. C. Spelsberg, R. C. Northcutt, H. L. Moses

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

[ 131I] 19-iodocholesterol (I-131 C) correctly located adrenocortical adenomas in four patients who had no clinical or biochemical evidence of excessive steroid production. Three of the four 'nonfunctioning' adenomas showed significant quantities of lipid histologically. To clarify the discordance between uptake and adrenal-steroid excretion, the subcellular location of I-131 C was studied. Normal rats and rats treated with ACTH or aminoglutethimide (AG) were injected intravenously with I-131 C or [ 3H] cholesterol (H-3 C) and killed after three days. The homogenized adrenals were subjected to subcellular fractionation. Treatment with AG increased both the amount and the percentage of both I-131 C and H-3 C contained in the lipid fraction. ACTH treatment decreased H-3 C content but did not change I-131 C content in the lipid layer, suggesting an impairment of I-131 C mobilization from lipid droplets. The data demonstrate that excess steroid production is not necessary for I-131 C uptake and provide an explanation why certain biochemically nonfunctioning adrenocortical adenomas are visualized with I-131 C.

Original languageEnglish (US)
Pages (from-to)458-463
Number of pages6
JournalJournal of Nuclear Medicine
Volume19
Issue number5
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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