Visual variant of Alzheimer disease: Distinctive neuropsychological features

Maura L. Furey-Kurkjian, Pietro Pietrini, Neill R Graff Radford, Gene E. Alexander, Ulderico Freo, Joanna Szczepanik, Mark B. Schapiro

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A subgroup of patients with probable Alzheimer disease (AD) reported a history of isolated visual disturbances (VS) early in the course of disease, without the characteristic memory complaints. Brain imaging and neuropathologic studies indicated that this subgroup had larger involvement of visual cortical areas and relative sparing of temporal, frontal, and limbic structures compared with classic AD. Consistent with these Endings, the authors hypothesized that the cognitive deficits in this subgroup would be distinctly different from those seen in more typical AD patients. The authors studied 10 probable AD patients with VS (AD+VS), 22 patients without VS (AD-), and 25 healthy controls with a neuropsychological test battery. Compared with AD-, AD+VS patients performed significantly better on tests of verbal memory and had greater impairment on tests of visuospatial skills, suggesting a distinct pattern of cognitive dysfunction consistent with metabolic and neuropathologic reports.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalNeuropsychology
Volume10
Issue number2
DOIs
StatePublished - 1996

Fingerprint

Alzheimer Disease
Neuropsychological Tests
Neuroimaging

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology

Cite this

Furey-Kurkjian, M. L., Pietrini, P., Graff Radford, N. R., Alexander, G. E., Freo, U., Szczepanik, J., & Schapiro, M. B. (1996). Visual variant of Alzheimer disease: Distinctive neuropsychological features. Neuropsychology, 10(2), 294-300. https://doi.org/10.1037/0894-4105.10.2.294

Visual variant of Alzheimer disease : Distinctive neuropsychological features. / Furey-Kurkjian, Maura L.; Pietrini, Pietro; Graff Radford, Neill R; Alexander, Gene E.; Freo, Ulderico; Szczepanik, Joanna; Schapiro, Mark B.

In: Neuropsychology, Vol. 10, No. 2, 1996, p. 294-300.

Research output: Contribution to journalArticle

Furey-Kurkjian, ML, Pietrini, P, Graff Radford, NR, Alexander, GE, Freo, U, Szczepanik, J & Schapiro, MB 1996, 'Visual variant of Alzheimer disease: Distinctive neuropsychological features', Neuropsychology, vol. 10, no. 2, pp. 294-300. https://doi.org/10.1037/0894-4105.10.2.294
Furey-Kurkjian, Maura L. ; Pietrini, Pietro ; Graff Radford, Neill R ; Alexander, Gene E. ; Freo, Ulderico ; Szczepanik, Joanna ; Schapiro, Mark B. / Visual variant of Alzheimer disease : Distinctive neuropsychological features. In: Neuropsychology. 1996 ; Vol. 10, No. 2. pp. 294-300.
@article{da66d26dfb3b4fd9beab5b6b38e972d2,
title = "Visual variant of Alzheimer disease: Distinctive neuropsychological features",
abstract = "A subgroup of patients with probable Alzheimer disease (AD) reported a history of isolated visual disturbances (VS) early in the course of disease, without the characteristic memory complaints. Brain imaging and neuropathologic studies indicated that this subgroup had larger involvement of visual cortical areas and relative sparing of temporal, frontal, and limbic structures compared with classic AD. Consistent with these Endings, the authors hypothesized that the cognitive deficits in this subgroup would be distinctly different from those seen in more typical AD patients. The authors studied 10 probable AD patients with VS (AD+VS), 22 patients without VS (AD-), and 25 healthy controls with a neuropsychological test battery. Compared with AD-, AD+VS patients performed significantly better on tests of verbal memory and had greater impairment on tests of visuospatial skills, suggesting a distinct pattern of cognitive dysfunction consistent with metabolic and neuropathologic reports.",
author = "Furey-Kurkjian, {Maura L.} and Pietro Pietrini and {Graff Radford}, {Neill R} and Alexander, {Gene E.} and Ulderico Freo and Joanna Szczepanik and Schapiro, {Mark B.}",
year = "1996",
doi = "10.1037/0894-4105.10.2.294",
language = "English (US)",
volume = "10",
pages = "294--300",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "American Psychological Association Inc.",
number = "2",

}

TY - JOUR

T1 - Visual variant of Alzheimer disease

T2 - Distinctive neuropsychological features

AU - Furey-Kurkjian, Maura L.

AU - Pietrini, Pietro

AU - Graff Radford, Neill R

AU - Alexander, Gene E.

AU - Freo, Ulderico

AU - Szczepanik, Joanna

AU - Schapiro, Mark B.

PY - 1996

Y1 - 1996

N2 - A subgroup of patients with probable Alzheimer disease (AD) reported a history of isolated visual disturbances (VS) early in the course of disease, without the characteristic memory complaints. Brain imaging and neuropathologic studies indicated that this subgroup had larger involvement of visual cortical areas and relative sparing of temporal, frontal, and limbic structures compared with classic AD. Consistent with these Endings, the authors hypothesized that the cognitive deficits in this subgroup would be distinctly different from those seen in more typical AD patients. The authors studied 10 probable AD patients with VS (AD+VS), 22 patients without VS (AD-), and 25 healthy controls with a neuropsychological test battery. Compared with AD-, AD+VS patients performed significantly better on tests of verbal memory and had greater impairment on tests of visuospatial skills, suggesting a distinct pattern of cognitive dysfunction consistent with metabolic and neuropathologic reports.

AB - A subgroup of patients with probable Alzheimer disease (AD) reported a history of isolated visual disturbances (VS) early in the course of disease, without the characteristic memory complaints. Brain imaging and neuropathologic studies indicated that this subgroup had larger involvement of visual cortical areas and relative sparing of temporal, frontal, and limbic structures compared with classic AD. Consistent with these Endings, the authors hypothesized that the cognitive deficits in this subgroup would be distinctly different from those seen in more typical AD patients. The authors studied 10 probable AD patients with VS (AD+VS), 22 patients without VS (AD-), and 25 healthy controls with a neuropsychological test battery. Compared with AD-, AD+VS patients performed significantly better on tests of verbal memory and had greater impairment on tests of visuospatial skills, suggesting a distinct pattern of cognitive dysfunction consistent with metabolic and neuropathologic reports.

UR - http://www.scopus.com/inward/record.url?scp=0029929459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029929459&partnerID=8YFLogxK

U2 - 10.1037/0894-4105.10.2.294

DO - 10.1037/0894-4105.10.2.294

M3 - Article

AN - SCOPUS:0029929459

VL - 10

SP - 294

EP - 300

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 2

ER -