Visual Function 15 Years after Optic Neuritis. A Final Follow-up Report from the Optic Neuritis Treatment Trial

Optic Neuritis Study Group

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Objective: To assess visual function 15 years after acute unilateral optic neuritis. Design: Longitudinal follow-up of a randomized clinical trial. Participants: Two hundred ninety-four patients who were randomized in the Optic Neuritis Treatment Trial between 1988 and 1991 and underwent examination in 2006. Testing: A neuro-ophthalmic examination included measurements of visual acuity, contrast sensitivity, and visual field. Quality of life was assessed with the National Eye Institute Visual Function Questionnaire and Neuro-ophthalmic Supplement. Main Outcome Measures: Abnormal vision and health-related quality-of-life scores. Results: Seventy-two percent of the eyes affected with optic neuritis at study entry had visual acuity of ≥ 20/20 and 66% of patients had ≥ 20/20 acuity in both eyes. On average, visual function was slightly worse among patients with multiple sclerosis (MS) than among with those without MS. As expected, quality-of-life scores were lower when acuity was reduced and when neurologic disability from MS was present. Conclusions: Long-term visual outcome is favorable for the majority of patients who experience optic neuritis even when MS is present.

Original languageEnglish (US)
Pages (from-to)1082.e5
JournalOphthalmology
Volume115
Issue number6
DOIs
StatePublished - Jun 1 2008

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Optic Neuritis
Multiple Sclerosis
Quality of Life
Visual Acuity
National Eye Institute (U.S.)
Contrast Sensitivity
Therapeutics
Visual Fields
Nervous System
Randomized Controlled Trials
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

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Visual Function 15 Years after Optic Neuritis. A Final Follow-up Report from the Optic Neuritis Treatment Trial. / Optic Neuritis Study Group.

In: Ophthalmology, Vol. 115, No. 6, 01.06.2008, p. 1082.e5.

Research output: Contribution to journalArticle

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abstract = "Objective: To assess visual function 15 years after acute unilateral optic neuritis. Design: Longitudinal follow-up of a randomized clinical trial. Participants: Two hundred ninety-four patients who were randomized in the Optic Neuritis Treatment Trial between 1988 and 1991 and underwent examination in 2006. Testing: A neuro-ophthalmic examination included measurements of visual acuity, contrast sensitivity, and visual field. Quality of life was assessed with the National Eye Institute Visual Function Questionnaire and Neuro-ophthalmic Supplement. Main Outcome Measures: Abnormal vision and health-related quality-of-life scores. Results: Seventy-two percent of the eyes affected with optic neuritis at study entry had visual acuity of ≥ 20/20 and 66{\%} of patients had ≥ 20/20 acuity in both eyes. On average, visual function was slightly worse among patients with multiple sclerosis (MS) than among with those without MS. As expected, quality-of-life scores were lower when acuity was reduced and when neurologic disability from MS was present. Conclusions: Long-term visual outcome is favorable for the majority of patients who experience optic neuritis even when MS is present.",
author = "{Optic Neuritis Study Group} and Gal, {Robin L.} and Michael Brodsky and Sarkis Nazarian and Shirley Hankins and Silvia Orengo-Nania and Hutton, {George J.} and Benita Slight and Pamela Frady and Buckley, {Edward G.} and Massey, {E. Wayne} and Anderson, {Malcolm M.} and Duncan, {Lois B.} and Bhatti, {M. Tariq} and Melvin Greer and Revonda Burke and Renae Preston and James Goodwin and Andrew Cross and Yesenia Garcia-Ovando and Michael Wall and Carmen Musser and Benita Carney and Reid Longmuir and Sandeep Randhawa and Vinay Shah and Savino, {Peter J.} and Thomas Leist and Andrea Stankiewicz and Reginald Edwards and Kert Gonzales and Miller, {Neil R.} and David Irani and Rhonda Miller and Lula West and Trobe, {Jonathan D.} and Wayne Cornblath and Sharon Boyk and Barbara Michael and Kaufman, {David I.} and Eric Eggenberger and Sandra Holliday and Doozie Snider and Kupersmith, {Mark J.} and Gary Mandel and Shults, {William T.} and Leslie McAllister and Mary Dierkes and Steve Hamilton and Galina Skalatsky and Beck, {Roy W.}",
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AU - Gal, Robin L.

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AU - Nazarian, Sarkis

AU - Hankins, Shirley

AU - Orengo-Nania, Silvia

AU - Hutton, George J.

AU - Slight, Benita

AU - Frady, Pamela

AU - Buckley, Edward G.

AU - Massey, E. Wayne

AU - Anderson, Malcolm M.

AU - Duncan, Lois B.

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AU - Musser, Carmen

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AU - Longmuir, Reid

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AU - Shah, Vinay

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AU - Leist, Thomas

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AU - Eggenberger, Eric

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AU - Kupersmith, Mark J.

AU - Mandel, Gary

AU - Shults, William T.

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AU - Skalatsky, Galina

AU - Beck, Roy W.

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