Visibility guided phase contrast denoising

Brandon Nelson, Thomas Koenig, Elisabeth Shanblatt, Shuai Leng, Cynthia H McCollough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Talbot-Lau grating interferometry enables the use of clinical x-ray tubes for phase contrast imaging, greatly broadening its utility for both laboratory and preclinical applications. However, phase contrast measurements made in porous or highly heterogeneous media are negatively impacted by low visibility, the interferometer signal amplitude used to calculate relative phase shifts. While this loss in visibility is the source of dark field contrast it presents an additional source of noise in phase images. In this work, we develop a method to use normalized visibility images as the weighting matrix for denoising the corresponding phase contrast images. By using the visibility to guide filtering, the resulting denoised images are locally smoothed in regions of low visibility while maintaining spatial detail in regions of high visibility. This work demonstrates how the complementary properties of the dark field signal in grating interferometry can be leveraged to improve image quality in phase contrast images and presents an application in preclinical lung micro-CT.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2019
Subtitle of host publicationPhysics of Medical Imaging
EditorsHilde Bosmans, Guang-Hong Chen, Taly Gilat Schmidt
PublisherSPIE
ISBN (Electronic)9781510625433
DOIs
StatePublished - Jan 1 2019
EventMedical Imaging 2019: Physics of Medical Imaging - San Diego, United States
Duration: Feb 17 2019Feb 20 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10948
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2019: Physics of Medical Imaging
CountryUnited States
CitySan Diego
Period2/17/192/20/19

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Keywords

  • Dark field
  • Denoising
  • Lung
  • Micro-CT
  • Phase contrast

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Nelson, B., Koenig, T., Shanblatt, E., Leng, S., & McCollough, C. H. (2019). Visibility guided phase contrast denoising. In H. Bosmans, G-H. Chen, & T. G. Schmidt (Eds.), Medical Imaging 2019: Physics of Medical Imaging [109484V] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10948). SPIE. https://doi.org/10.1117/12.2511212