Viscoelastic properties of normal and infarcted myocardium measured by a multifrequency shear wave method: Comparison with pressure-segment length method

Cristina Pislaru, Matthew W. Urban, Sorin V. Pislaru, Randall R. Kinnick, James F. Greenleaf

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Our aims were (i) to compare in vivo measurements of myocardial elasticity by shear wave dispersion ultrasound vibrometry (SDUV) with those by the conventional pressure-segment length method, and (ii) to quantify changes in myocardial viscoelasticity during systole and diastole after reperfused acute myocardial infarction. The shear elastic modulus (μ1) and viscous coefficient (μ2) of left ventricular myocardium were measured by SDUV in 10 pigs. Young's elastic modulus was independently measured by the pressure-segment length method. Measurements made with the SDUV and pressure-segment length methods were strongly correlated. At reperfusion, μ1 and μ2 in end-diastole were increased. Less consistent changes were found during systole. In all animals, μ1 increased linearly with left ventricular pressure developed during systole. Preliminary results suggest that μ1 is preload dependent. This is the first study to validate in vivo measurements of myocardial elasticity by a shear wave method. In this animal model, the alterations in myocardial viscoelasticity after a myocardial infarction were most consistently detected during diastole.

Original languageEnglish (US)
Pages (from-to)1785-1795
Number of pages11
JournalUltrasound in Medicine and Biology
Volume40
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Echocardiography
  • Elasticity
  • Elastography
  • Myocardial infarction
  • Myocardial stiffness
  • Shear elasticity
  • Shear wave
  • Ultrasound
  • Viscoelasticity

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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