Viscoelastic properties of normal and infarcted myocardium measured by a multifrequency shear wave method: Comparison with pressure-segment length method

Cristina D Pislaru, Matthew W Urban, Sorin V. Pislaru, Randall R. Kinnick, James F Greenleaf

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24 Citations (Scopus)

Abstract

Our aims were (i) to compare in vivo measurements of myocardial elasticity by shear wave dispersion ultrasound vibrometry (SDUV) with those by the conventional pressure-segment length method, and (ii) to quantify changes in myocardial viscoelasticity during systole and diastole after reperfused acute myocardial infarction. The shear elastic modulus (μ1) and viscous coefficient (μ2) of left ventricular myocardium were measured by SDUV in 10 pigs. Young's elastic modulus was independently measured by the pressure-segment length method. Measurements made with the SDUV and pressure-segment length methods were strongly correlated. At reperfusion, μ1 and μ2 in end-diastole were increased. Less consistent changes were found during systole. In all animals, μ1 increased linearly with left ventricular pressure developed during systole. Preliminary results suggest that μ1 is preload dependent. This is the first study to validate in vivo measurements of myocardial elasticity by a shear wave method. In this animal model, the alterations in myocardial viscoelasticity after a myocardial infarction were most consistently detected during diastole.

Original languageEnglish (US)
Pages (from-to)1785-1795
Number of pages11
JournalUltrasound in Medicine and Biology
Volume40
Issue number8
DOIs
StatePublished - 2014

Fingerprint

myocardium
diastole
systole
S waves
Diastole
wave dispersion
Elastic Modulus
Systole
Myocardium
myocardial infarction
Pressure
viscoelasticity
Elasticity
modulus of elasticity
elastic properties
Myocardial Infarction
animal models
swine
Ventricular Pressure
Reperfusion

Keywords

  • Echocardiography
  • Elasticity
  • Elastography
  • Myocardial infarction
  • Myocardial stiffness
  • Shear elasticity
  • Shear wave
  • Ultrasound
  • Viscoelasticity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics
  • Medicine(all)

Cite this

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title = "Viscoelastic properties of normal and infarcted myocardium measured by a multifrequency shear wave method: Comparison with pressure-segment length method",
abstract = "Our aims were (i) to compare in vivo measurements of myocardial elasticity by shear wave dispersion ultrasound vibrometry (SDUV) with those by the conventional pressure-segment length method, and (ii) to quantify changes in myocardial viscoelasticity during systole and diastole after reperfused acute myocardial infarction. The shear elastic modulus (μ1) and viscous coefficient (μ2) of left ventricular myocardium were measured by SDUV in 10 pigs. Young's elastic modulus was independently measured by the pressure-segment length method. Measurements made with the SDUV and pressure-segment length methods were strongly correlated. At reperfusion, μ1 and μ2 in end-diastole were increased. Less consistent changes were found during systole. In all animals, μ1 increased linearly with left ventricular pressure developed during systole. Preliminary results suggest that μ1 is preload dependent. This is the first study to validate in vivo measurements of myocardial elasticity by a shear wave method. In this animal model, the alterations in myocardial viscoelasticity after a myocardial infarction were most consistently detected during diastole.",
keywords = "Echocardiography, Elasticity, Elastography, Myocardial infarction, Myocardial stiffness, Shear elasticity, Shear wave, Ultrasound, Viscoelasticity",
author = "Pislaru, {Cristina D} and Urban, {Matthew W} and Pislaru, {Sorin V.} and Kinnick, {Randall R.} and Greenleaf, {James F}",
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AU - Pislaru, Cristina D

AU - Urban, Matthew W

AU - Pislaru, Sorin V.

AU - Kinnick, Randall R.

AU - Greenleaf, James F

PY - 2014

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KW - Ultrasound

KW - Viscoelasticity

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