Visceral perception in irritable bowel syndrome - Rectal and gastric responses to distension and serotonin type 3 antagonism

Jaime Zighelboim, Nicholas J. Talley, Sidney F. Phillips, William S. Harmsen, Alan R. Zinsmeister

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


We wished to determine if visceral perception in the rectum and stomach is altered in patients with irritable bowel syndrome and to evaluate the effects on visceral sensation of 5-HT3 receptor blockade. Twelve community patients with diarrhea-predominant irritable bowel syndrome and 10 healthy controls were studied in a double-blind, randomized, placebo-controlled study. Using two barostats, the stomach and rectum were distended, with pressure increments of 4 mm Hg, from 10 to 26 mm Hg; visceral perception was measured on an ordinal scale of 0-10. Personality traits were measured using standard psychological methods, and somatic pain was evaluated by immersion of the nondominant hand in cold water. The effect of 5-HT3 antagonism was tested with a single intravenous dose of ondansetron at 0.15 mg/kg. Gastric perception was higher in irritable bowel syndrome, but rectal distension was perceived similarly in irritable bowel syndrome and controls. Pain tolerance to cold water was also similar in irritable bowel syndrome and controls. Ondansetron induced rectal relaxation and increased rectal compliance but did not significantly alter gastric compliance or visceral perception. Psychological test scores were similar in patients and controls. We conclude that in this group of psychologically normal patients with irritable bowel syndrome, who were not chronic health-care seekers, visceral perception was normal. Ondansetron did not alter gut perception in health or in irritable bowel syndrome.

Original languageEnglish (US)
Pages (from-to)819-827
Number of pages9
JournalDigestive diseases and sciences
Issue number4
StatePublished - Apr 1995


  • gastric and rectal distension
  • irritable bowel syndrome
  • ondansetron

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


Dive into the research topics of 'Visceral perception in irritable bowel syndrome - Rectal and gastric responses to distension and serotonin type 3 antagonism'. Together they form a unique fingerprint.

Cite this