Virus persists in beta cells of islet of Langerhans and infection is associated with chemical manifestations of diabetes. II. Morphologic observations

M. Rodriguez, R. S. Garrett, M. Raitt, P. W. Lampert, M. B. Oldstone

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Persistence of lymphocytic choriomeningitis (LCM) virus in the islet of Langerhans was associated with mild hyperglycemia and abnormal glucose tolerance test results. Early histopathologic events consisted of occasional perivascular inflammatory mononuclear cells around both islet and acinar cells. Morphometric studies showed an increase in the size of islets from virus-infected mice. By electron microscopy, LCM virions were found within infected beta cells. Cytolytic injury of beta cells was minimal and did not account for the abnormalities of glucose metabolism. In contrast to the findings in islets, ultrastructural studies of acinar cells revealed LCM virions in abundance, vacuolar degeneration, and intracytoplasmic inclusions. This study extends the previous observation that LCM virus infection may persist in beta cells of the islets of Langerhans without causing structural injury but be associated with abnormalities resembling the chemical and histopathologic features of the early stage of Type II (adult-onset) human diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalAmerican Journal of Pathology
Volume121
Issue number3
StatePublished - 1985

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Islets of Langerhans
Lymphocytic Choriomeningitis
Viruses
Lymphocytic choriomeningitis virus
Acinar Cells
Infection
Virion
Wounds and Injuries
Virus Diseases
Glucose Tolerance Test
Hyperglycemia
Type 2 Diabetes Mellitus
Electron Microscopy
Glucose

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Virus persists in beta cells of islet of Langerhans and infection is associated with chemical manifestations of diabetes. II. Morphologic observations. / Rodriguez, M.; Garrett, R. S.; Raitt, M.; Lampert, P. W.; Oldstone, M. B.

In: American Journal of Pathology, Vol. 121, No. 3, 1985, p. 497-504.

Research output: Contribution to journalArticle

Rodriguez, M. ; Garrett, R. S. ; Raitt, M. ; Lampert, P. W. ; Oldstone, M. B. / Virus persists in beta cells of islet of Langerhans and infection is associated with chemical manifestations of diabetes. II. Morphologic observations. In: American Journal of Pathology. 1985 ; Vol. 121, No. 3. pp. 497-504.
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