TY - JOUR
T1 - Virus-Induced Demyelination in Mice
T2 - “Dying Back” of Oligodendrocytes
AU - RODRIGUEZ, MOSES
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - Demyelination was produced in mice by intracerebral inoculation of Theiler's murine encephalomyelitis virus. The earliest ultrastructural changes occurred in the inner cytoplasmic tongues of oligodendrocytes, the most distal extension of these cells. Viral antigen was localized to glial loops that connect with myelin lamellae. This study indicates that a “dying-back” process may occur in virus-infected oligodendrocytes, which then results in demyelination.
AB - Demyelination was produced in mice by intracerebral inoculation of Theiler's murine encephalomyelitis virus. The earliest ultrastructural changes occurred in the inner cytoplasmic tongues of oligodendrocytes, the most distal extension of these cells. Viral antigen was localized to glial loops that connect with myelin lamellae. This study indicates that a “dying-back” process may occur in virus-infected oligodendrocytes, which then results in demyelination.
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U2 - 10.1016/S0025-6196(12)60865-9
DO - 10.1016/S0025-6196(12)60865-9
M3 - Article
C2 - 4040195
AN - SCOPUS:0022253157
SN - 0025-6196
VL - 60
SP - 433
EP - 438
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 7
ER -