Virus-induced demyelination in mice: 'Dying back' of oligodendrocytes

M. Rodriguez

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Demyelination was produced in mice by intracerebral inoculation of Theiler's murine encephalomyelitis virus. The earliest ultrastructural changes occurred in the inner cytoplasmic tongues of oligodendrocytes, the most distal extension of these cells. Viral antigen was localized to glial loops that connect with myelin lamellae. This study indicates that a 'dying-back' process may occur in virus-infected oligodendrocytes, which then results in demyelination.

Original languageEnglish (US)
Pages (from-to)433-438
Number of pages6
JournalMayo Clinic Proceedings
Volume60
Issue number7
StatePublished - 1985
Externally publishedYes

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Oligodendroglia
Demyelinating Diseases
Theilovirus
Viruses
Viral Antigens
Myelin Sheath
Tongue
Neuroglia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Virus-induced demyelination in mice : 'Dying back' of oligodendrocytes. / Rodriguez, M.

In: Mayo Clinic Proceedings, Vol. 60, No. 7, 1985, p. 433-438.

Research output: Contribution to journalArticle

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