Virus-Based Cancer Therapeutics

Roberto Cattaneo; Christine E. Engeland

doi:10.1016/B978-0-12-814515-9.00091-6

Virus-Based Cancer Therapeutics

Roberto Cattaneo, Christine E. Engeland

Molecular Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The concept of treating cancer with viruses originates from early 20th century clinical reports associating cancer regression with infections of natural viruses. In the last three decades, viruses have been genetically modified for greater tumor specificity and enhanced oncolytic activity. A modified herpes simplex virus and a recombinant adenovirus are currently licensed for specific cancer treatments. Viruses from other seven families are in advanced clinical trials of oncolysis. Virus-based cancer therapeutics, in combination with chemotherapy, immunotherapy, and radiation, are just beginning to find their place in clinical practice.

Original language	English (US)
Title of host publication	Encyclopedia of Virology
Subtitle of host publication	Volume 1-5, Fourth Edition
Publisher	Elsevier
Pages	233-244
Number of pages	12
Volume	1-5
ISBN (Electronic)	9780128145166
DOIs	https://doi.org/10.1016/B978-0-12-814515-9.00091-6
State	Published - Jan 1 2020

Keywords

Adenoviridae
Cancer treatment
Genetic engineering
Herpesviridae
Oncolysis
Paramyxoviridae
Parvoviridae
Picornaviridae
Poxviridae
Reoviridae
Retroviridae
Rhabdoviridae
Therapeutic viruses
Tumor specificity

ASJC Scopus subject areas

General Immunology and Microbiology

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10.1016/B978-0-12-814515-9.00091-6

Cite this

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abstract = "The concept of treating cancer with viruses originates from early 20th century clinical reports associating cancer regression with infections of natural viruses. In the last three decades, viruses have been genetically modified for greater tumor specificity and enhanced oncolytic activity. A modified herpes simplex virus and a recombinant adenovirus are currently licensed for specific cancer treatments. Viruses from other seven families are in advanced clinical trials of oncolysis. Virus-based cancer therapeutics, in combination with chemotherapy, immunotherapy, and radiation, are just beginning to find their place in clinical practice.",

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KW - Adenoviridae

KW - Cancer treatment

KW - Genetic engineering

KW - Herpesviridae

KW - Oncolysis

KW - Paramyxoviridae

KW - Parvoviridae

KW - Picornaviridae

KW - Poxviridae

KW - Reoviridae

KW - Retroviridae

KW - Rhabdoviridae

KW - Therapeutic viruses

KW - Tumor specificity

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ER -

Virus-Based Cancer Therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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