Viral vector targeting

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

The field of viral vector targeting is advancing rapidly. Recent advances include the successful use of bifunctional crosslinkers to target adenoviral and retroviral vectors, elucidation of the crystal structures of an adenoviral and a retroviral receptor-binding domain, and definition of strategies for inserting short targeting peptides and larger polypeptide-binding domains into the coat proteins of a number of different viral vectors. Novel targeting strategies based on host range restriction and protease activation have been developed, targeted replication-competent vectors have shown promise as anti-cancer agents and the possibility of selecting targeted vectors from vector display libraries has been established.

Original languageEnglish (US)
Pages (from-to)454-457
Number of pages4
JournalCurrent Opinion in Biotechnology
Volume10
Issue number5
DOIs
StatePublished - Oct 1 1999

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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