Viral vector targeting

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The field of viral vector targeting is advancing rapidly. Recent advances include the successful use of bifunctional crosslinkers to target adenoviral and retroviral vectors, elucidation of the crystal structures of an adenoviral and a retroviral receptor-binding domain, and definition of strategies for inserting short targeting peptides and larger polypeptide-binding domains into the coat proteins of a number of different viral vectors. Novel targeting strategies based on host range restriction and protease activation have been developed, targeted replication-competent vectors have shown promise as anti-cancer agents and the possibility of selecting targeted vectors from vector display libraries has been established.

Original languageEnglish (US)
Pages (from-to)454-457
Number of pages4
JournalCurrent Opinion in Biotechnology
Volume10
Issue number5
DOIs
StatePublished - Oct 1 1999

Fingerprint

Peptides
Host Specificity
Capsid Proteins
Libraries
Peptide Hydrolases
Neoplasms
Polypeptides
Crystal structure
Chemical activation
Display devices
Proteins

ASJC Scopus subject areas

  • Biotechnology

Cite this

Viral vector targeting. / Peng, Kah-Whye; Russell, Stephen J.

In: Current Opinion in Biotechnology, Vol. 10, No. 5, 01.10.1999, p. 454-457.

Research output: Contribution to journalArticle

@article{df8d2840ec3647828a8829fdd8ffb1ad,
title = "Viral vector targeting",
abstract = "The field of viral vector targeting is advancing rapidly. Recent advances include the successful use of bifunctional crosslinkers to target adenoviral and retroviral vectors, elucidation of the crystal structures of an adenoviral and a retroviral receptor-binding domain, and definition of strategies for inserting short targeting peptides and larger polypeptide-binding domains into the coat proteins of a number of different viral vectors. Novel targeting strategies based on host range restriction and protease activation have been developed, targeted replication-competent vectors have shown promise as anti-cancer agents and the possibility of selecting targeted vectors from vector display libraries has been established.",
author = "Kah-Whye Peng and Russell, {Stephen J}",
year = "1999",
month = "10",
day = "1",
doi = "10.1016/S0958-1669(99)00009-9",
language = "English (US)",
volume = "10",
pages = "454--457",
journal = "Current Opinion in Biotechnology",
issn = "0958-1669",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Viral vector targeting

AU - Peng, Kah-Whye

AU - Russell, Stephen J

PY - 1999/10/1

Y1 - 1999/10/1

N2 - The field of viral vector targeting is advancing rapidly. Recent advances include the successful use of bifunctional crosslinkers to target adenoviral and retroviral vectors, elucidation of the crystal structures of an adenoviral and a retroviral receptor-binding domain, and definition of strategies for inserting short targeting peptides and larger polypeptide-binding domains into the coat proteins of a number of different viral vectors. Novel targeting strategies based on host range restriction and protease activation have been developed, targeted replication-competent vectors have shown promise as anti-cancer agents and the possibility of selecting targeted vectors from vector display libraries has been established.

AB - The field of viral vector targeting is advancing rapidly. Recent advances include the successful use of bifunctional crosslinkers to target adenoviral and retroviral vectors, elucidation of the crystal structures of an adenoviral and a retroviral receptor-binding domain, and definition of strategies for inserting short targeting peptides and larger polypeptide-binding domains into the coat proteins of a number of different viral vectors. Novel targeting strategies based on host range restriction and protease activation have been developed, targeted replication-competent vectors have shown promise as anti-cancer agents and the possibility of selecting targeted vectors from vector display libraries has been established.

UR - http://www.scopus.com/inward/record.url?scp=0032861707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032861707&partnerID=8YFLogxK

U2 - 10.1016/S0958-1669(99)00009-9

DO - 10.1016/S0958-1669(99)00009-9

M3 - Article

VL - 10

SP - 454

EP - 457

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

IS - 5

ER -