Viral and fungal infection after liver transplantation - Part II

Shimon Kusne, Janis E. Blair

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Viral and fungal infections in liver transplant recipients are important to recognize and treat early because of their association with substantial morbidity and mortality. Some viruses, such as cytomegalovirus and human herpesvirus 6, have immunomodulatory properties and can facilitate other infections, including fungal infections. Cytomegalovirus has long been recognized as an important virus in transplantation, but in the past decade other viruses have also received attention in the medical literature because of their association with particular clinical syndromes. Although human herpesvirus 6 has been associated with fever, rash, and encephalitis, a direct cause-and-effect relationship is still lacking. Human herpesvirus 8 has been found to be the cause of Kaposi sarcoma. Molecular techniques (e.g., pp65 antigenemia and polymerase chain reaction) that have been introduced for routine diagnosis of viruses have facilitated the diagnosis of asymptomatic viral infections and the institution of preemptive therapy. Nonetheless, the diagnosis of invasive fungal infections in liver transplant recipients is often delayed and thus associated with high mortality. Despite the use of new antifungal agents in clinical practice and the reduced incidence of fungal infections because of antifungal prophylaxis regimens, mortality has not decreased. Future patient outcomes may improve with early identification of patients who have risk factors for invasive fungal infections and with the development of new molecular diagnostic techniques for early detection.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalLiver Transplantation
Volume12
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Mycoses
Virus Diseases
Liver Transplantation
Viruses
Human Herpesvirus 6
Cytomegalovirus
Mortality
Molecular Diagnostic Techniques
Human Herpesvirus 8
Asymptomatic Infections
Antifungal Agents
Kaposi's Sarcoma
Liver
Encephalitis
Exanthema
Fever
Transplantation
Morbidity
Polymerase Chain Reaction
Incidence

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Viral and fungal infection after liver transplantation - Part II. / Kusne, Shimon; Blair, Janis E.

In: Liver Transplantation, Vol. 12, No. 1, 01.2006, p. 2-12.

Research output: Contribution to journalArticle

Kusne, Shimon ; Blair, Janis E. / Viral and fungal infection after liver transplantation - Part II. In: Liver Transplantation. 2006 ; Vol. 12, No. 1. pp. 2-12.
@article{a3a647d115b14543ad3fcab5fc22eb46,
title = "Viral and fungal infection after liver transplantation - Part II",
abstract = "Viral and fungal infections in liver transplant recipients are important to recognize and treat early because of their association with substantial morbidity and mortality. Some viruses, such as cytomegalovirus and human herpesvirus 6, have immunomodulatory properties and can facilitate other infections, including fungal infections. Cytomegalovirus has long been recognized as an important virus in transplantation, but in the past decade other viruses have also received attention in the medical literature because of their association with particular clinical syndromes. Although human herpesvirus 6 has been associated with fever, rash, and encephalitis, a direct cause-and-effect relationship is still lacking. Human herpesvirus 8 has been found to be the cause of Kaposi sarcoma. Molecular techniques (e.g., pp65 antigenemia and polymerase chain reaction) that have been introduced for routine diagnosis of viruses have facilitated the diagnosis of asymptomatic viral infections and the institution of preemptive therapy. Nonetheless, the diagnosis of invasive fungal infections in liver transplant recipients is often delayed and thus associated with high mortality. Despite the use of new antifungal agents in clinical practice and the reduced incidence of fungal infections because of antifungal prophylaxis regimens, mortality has not decreased. Future patient outcomes may improve with early identification of patients who have risk factors for invasive fungal infections and with the development of new molecular diagnostic techniques for early detection.",
author = "Shimon Kusne and Blair, {Janis E.}",
year = "2006",
month = "1",
doi = "10.1002/lt.20667",
language = "English (US)",
volume = "12",
pages = "2--12",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Viral and fungal infection after liver transplantation - Part II

AU - Kusne, Shimon

AU - Blair, Janis E.

PY - 2006/1

Y1 - 2006/1

N2 - Viral and fungal infections in liver transplant recipients are important to recognize and treat early because of their association with substantial morbidity and mortality. Some viruses, such as cytomegalovirus and human herpesvirus 6, have immunomodulatory properties and can facilitate other infections, including fungal infections. Cytomegalovirus has long been recognized as an important virus in transplantation, but in the past decade other viruses have also received attention in the medical literature because of their association with particular clinical syndromes. Although human herpesvirus 6 has been associated with fever, rash, and encephalitis, a direct cause-and-effect relationship is still lacking. Human herpesvirus 8 has been found to be the cause of Kaposi sarcoma. Molecular techniques (e.g., pp65 antigenemia and polymerase chain reaction) that have been introduced for routine diagnosis of viruses have facilitated the diagnosis of asymptomatic viral infections and the institution of preemptive therapy. Nonetheless, the diagnosis of invasive fungal infections in liver transplant recipients is often delayed and thus associated with high mortality. Despite the use of new antifungal agents in clinical practice and the reduced incidence of fungal infections because of antifungal prophylaxis regimens, mortality has not decreased. Future patient outcomes may improve with early identification of patients who have risk factors for invasive fungal infections and with the development of new molecular diagnostic techniques for early detection.

AB - Viral and fungal infections in liver transplant recipients are important to recognize and treat early because of their association with substantial morbidity and mortality. Some viruses, such as cytomegalovirus and human herpesvirus 6, have immunomodulatory properties and can facilitate other infections, including fungal infections. Cytomegalovirus has long been recognized as an important virus in transplantation, but in the past decade other viruses have also received attention in the medical literature because of their association with particular clinical syndromes. Although human herpesvirus 6 has been associated with fever, rash, and encephalitis, a direct cause-and-effect relationship is still lacking. Human herpesvirus 8 has been found to be the cause of Kaposi sarcoma. Molecular techniques (e.g., pp65 antigenemia and polymerase chain reaction) that have been introduced for routine diagnosis of viruses have facilitated the diagnosis of asymptomatic viral infections and the institution of preemptive therapy. Nonetheless, the diagnosis of invasive fungal infections in liver transplant recipients is often delayed and thus associated with high mortality. Despite the use of new antifungal agents in clinical practice and the reduced incidence of fungal infections because of antifungal prophylaxis regimens, mortality has not decreased. Future patient outcomes may improve with early identification of patients who have risk factors for invasive fungal infections and with the development of new molecular diagnostic techniques for early detection.

UR - http://www.scopus.com/inward/record.url?scp=33645100314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645100314&partnerID=8YFLogxK

U2 - 10.1002/lt.20667

DO - 10.1002/lt.20667

M3 - Article

C2 - 16382451

AN - SCOPUS:33645100314

VL - 12

SP - 2

EP - 12

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 1

ER -