Treatment of autoimmune hemolytic anemia with corticosteroids, splenectomy, immune suppression, and plasma exchange, serially or in combination, often yields partial or short remissions. We describe a patient in whom refractory autoimmune hemolytic anemia was moderated by selective impairment of the mononuclear-phagocyte system by means of infusion of vinblastine-loaded platelets. The success of this approach, initially proposed for treatment of immune thrombocytopenic purpura, suggests that erythrocytes and platelets share a common site of immune destruction and that the rate of this destruction is determined by the phagocyte.
ASJC Scopus subject areas
- Internal Medicine