Vinblastine-loaded platelets for autoimmune hemolytic anemia

Morie Gertz, R. M. Petitt, A. A. Pineda, M. R. Wick, E. A. Burgstaler

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Treatment of autoimmune hemolytic anemia with corticosteroids, splenectomy, immune suppression, and plasma exchange, serially or in combination, often yields partial or short remissions. We describe a patient in whom refractory autoimmune hemolytic anemia was moderated by selective impairment of the mononuclear-phagocyte system by means of infusion of vinblastine-loaded platelets. The success of this approach, initially proposed for treatment of immune thrombocytopenic purpura, suggests that erythrocytes and platelets share a common site of immune destruction and that the rate of this destruction is determined by the phagocyte.

Original languageEnglish (US)
Pages (from-to)325-326
Number of pages2
JournalUnknown Journal
Volume95
Issue number3
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Internal Medicine

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