Vibro-acoustic tissue mammography

Mostafa Fatemi; Lester E. Wold; Azra Alizad; James F. Greenleaf

doi:10.1109/42.981229

Vibro-acoustic tissue mammography

Mostafa Fatemi, Lester E. Wold, Azra Alizad, James F. Greenleaf

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

A novel method for detection and imaging of microcalcifications in breast tissue is presented. The method, called vibro-acoustography, uses the radiation force of ultrasound to vibrate tissue at low (kHz) frequency and utilizes the resulting response to produce images that are related to the hardness of the tissue. The method is tested on human breast tissues. The resulting vibro-acoustographic images are in agreement with corresponding X-ray mammography images of the specimens. The existence of microcalcifications in locations indicated by vibro-acoustography is confirmed by histology. Microcalcifications as small as 110 μm in diameter are detected by this method. Resulting vibro-acoustographic images show microcalcifications with high contrast with respect to the background soft tissue. Structures such as dense sclerotic tissue do not seem to interfere with detection of microcalcifications.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	IEEE transactions on medical imaging
Volume	21
Issue number	1
DOIs	https://doi.org/10.1109/42.981229
State	Published - Jan 2002

Keywords

Breast
Mammography
Microcalcifications
Ultrasound
Vibro-acoustography

ASJC Scopus subject areas

Software
Radiological and Ultrasound Technology
Computer Science Applications
Electrical and Electronic Engineering

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10.1109/42.981229

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title = "Vibro-acoustic tissue mammography",

abstract = "A novel method for detection and imaging of microcalcifications in breast tissue is presented. The method, called vibro-acoustography, uses the radiation force of ultrasound to vibrate tissue at low (kHz) frequency and utilizes the resulting response to produce images that are related to the hardness of the tissue. The method is tested on human breast tissues. The resulting vibro-acoustographic images are in agreement with corresponding X-ray mammography images of the specimens. The existence of microcalcifications in locations indicated by vibro-acoustography is confirmed by histology. Microcalcifications as small as 110 μm in diameter are detected by this method. Resulting vibro-acoustographic images show microcalcifications with high contrast with respect to the background soft tissue. Structures such as dense sclerotic tissue do not seem to interfere with detection of microcalcifications.",

keywords = "Breast, Mammography, Microcalcifications, Ultrasound, Vibro-acoustography",

author = "Mostafa Fatemi and Wold, {Lester E.} and Azra Alizad and Greenleaf, {James F.}",

note = "Funding Information: Manuscript received April 30, 2001; revised November 20, 2001. This work was supported by the Army Medical Research and Material Command under Grant DAMD 17-98-1-8121. The Associate Editor responsible for coordinating the review of this paper and recommending its publication was M. Insana. Asterisk indicates corresponding author. *M. Fatemi is with the Basic Ultrasound Research Laboratory, Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905 USA (e-mail: fatemi.mostafa@mayo.edu).",

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N2 - A novel method for detection and imaging of microcalcifications in breast tissue is presented. The method, called vibro-acoustography, uses the radiation force of ultrasound to vibrate tissue at low (kHz) frequency and utilizes the resulting response to produce images that are related to the hardness of the tissue. The method is tested on human breast tissues. The resulting vibro-acoustographic images are in agreement with corresponding X-ray mammography images of the specimens. The existence of microcalcifications in locations indicated by vibro-acoustography is confirmed by histology. Microcalcifications as small as 110 μm in diameter are detected by this method. Resulting vibro-acoustographic images show microcalcifications with high contrast with respect to the background soft tissue. Structures such as dense sclerotic tissue do not seem to interfere with detection of microcalcifications.

AB - A novel method for detection and imaging of microcalcifications in breast tissue is presented. The method, called vibro-acoustography, uses the radiation force of ultrasound to vibrate tissue at low (kHz) frequency and utilizes the resulting response to produce images that are related to the hardness of the tissue. The method is tested on human breast tissues. The resulting vibro-acoustographic images are in agreement with corresponding X-ray mammography images of the specimens. The existence of microcalcifications in locations indicated by vibro-acoustography is confirmed by histology. Microcalcifications as small as 110 μm in diameter are detected by this method. Resulting vibro-acoustographic images show microcalcifications with high contrast with respect to the background soft tissue. Structures such as dense sclerotic tissue do not seem to interfere with detection of microcalcifications.

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Vibro-acoustic tissue mammography

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Keywords

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