Vibration safety limits for magnetic resonance elastography

Eric Ehman, P. J. Rossman, S. A. Kruse, A. V. Sahakian, K. J. Glaser

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Magnetic resonance elastography (MRE) has been demonstrated to have potential as a clinical tool for assessing the stiffness of tissue in vivo. An essential step in MRE is the generation of acoustic mechanical waves within a tissue via a coupled mechanical driver. Motivated by an increasing volume of human imaging trials using MRE, the objectives of this study were to audit the vibration amplitude of exposure for our IRB-approved human MRE studies, to compare these values to a conservative regulatory standard for vibrational exposure and to evaluate the applicability and implications of this standard for MRE. MRE displacement data were examined from 29 MRE exams, including the liver, brain, kidney, breast and skeletal muscle. Vibrational acceleration limits from a European Union directive limiting occupational exposure to whole-body and extremity vibrations (EU 2002/44/EC) were adjusted for time and frequency of exposure, converted to maximum displacement values and compared to the measured in vivo displacements. The results indicate that the vibrational amplitudes used in MRE studies are below the EU whole-body vibration limit, and the EU guidelines represent a useful standard that could be readily accepted by Institutional Review Boards to define standards for vibrational exposures for MRE studies in humans.

Original languageEnglish (US)
Pages (from-to)925-935
Number of pages11
JournalPhysics in medicine and biology
Volume53
Issue number4
DOIs
StatePublished - Feb 18 2008

Fingerprint

Elasticity Imaging Techniques
Vibration
Safety
Research Ethics Committees
European Union
Occupational Exposure
Skeletal Muscle
Breast
Extremities
Guidelines
Kidney

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Vibration safety limits for magnetic resonance elastography. / Ehman, Eric; Rossman, P. J.; Kruse, S. A.; Sahakian, A. V.; Glaser, K. J.

In: Physics in medicine and biology, Vol. 53, No. 4, 18.02.2008, p. 925-935.

Research output: Contribution to journalArticle

Ehman, Eric ; Rossman, P. J. ; Kruse, S. A. ; Sahakian, A. V. ; Glaser, K. J. / Vibration safety limits for magnetic resonance elastography. In: Physics in medicine and biology. 2008 ; Vol. 53, No. 4. pp. 925-935.
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