Vesicle formation at the plasma membrane and trans-Golgi network: The same but different

Mark A. McNiven; Heather M. Thompson

doi:10.1126/science.1118133

Vesicle formation at the plasma membrane and trans-Golgi network: The same but different

Mark A. McNiven, Heather M. Thompson

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

An elaborate vesicle transport system supports the active exchange of membranes and protein cargo between the plasma membrane and the trans-Golgi network. Many observations suggest that highly conserved mechanisms are used in vesicle formation and scission. Such similarity is found both at the level of the receptor-ligand sequestration process that uses clathrin and associated polymeric and monomeric adaptor proteins, and in the machinery used to deform and vesiculate lipid membranes.

Original language	English (US)
Pages (from-to)	1591-1594
Number of pages	4
Journal	Science
Volume	313
Issue number	5793
DOIs	https://doi.org/10.1126/science.1118133
State	Published - Sep 15 2006

ASJC Scopus subject areas

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