Vesicle formation at the plasma membrane and trans-Golgi network: The same but different

Mark A. McNiven, Heather M. Thompson

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

An elaborate vesicle transport system supports the active exchange of membranes and protein cargo between the plasma membrane and the trans-Golgi network. Many observations suggest that highly conserved mechanisms are used in vesicle formation and scission. Such similarity is found both at the level of the receptor-ligand sequestration process that uses clathrin and associated polymeric and monomeric adaptor proteins, and in the machinery used to deform and vesiculate lipid membranes.

Original languageEnglish (US)
Pages (from-to)1591-1594
Number of pages4
JournalScience
Volume313
Issue number5793
DOIs
StatePublished - Sep 15 2006

ASJC Scopus subject areas

  • General

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