Vertical gradients in regional lung density and perfusion in the supine human lung

The Slinky effect

Susan R. Hopkins, A. Cortney Henderson, David L. Levin, Kei Yamada, Tatsuya Arai, Richard B. Buxton, G. Kim Prisk

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

In vivo radioactive tracer and microsphere studies have differing conclusions as to the magnitude of the gravitational effect on the distribution of pulmonary blood flow. We hypothesized that some of the apparent vertical perfusion gradient in vivo is due to compression of dependent lung increasing local lung density and therefore perfusion/volume. To test this, six normal subjects underwent functional magnetic resonance imaging with arterial spin labeling during breath holding at functional residual capacity, and perfusion quantified in nonoverlapping 15 mm sagittal slices covering most of the right lung. Lung proton density was measured in the same slices using a short echo 2D-Fast Low-Angle SHot (FLASH) sequence. Mean perfusion was 1.7 ± 0.6 ml·min-1·cm-3 and was related to vertical height above the dependent lung (slope= -3%/cm, P < 0.0001). Lung density averaged 0.34 ± 0.08 g/cm3 and was also related to vertical height (slope = -4.9%/cm, P < 0.0001). By contrast, when perfusion was normalized for regional lung density, the slope of the height-perfusion relationship was not significantly different from zero (P = 0.2). This suggests that in vivo variations in regional lung density affect the interpretation of vertical gradients in pulmonary blood flow and is consistent with a simple conceptual model: the lung behaves like a Slinky (Slinky is a registered trademark of Poof-Slinky Incorporated), a deformable spring distorting under its own weight. The greater density of lung tissue in the dependent regions of the lung is analogous to a greater number of coils in the dependent portion of the vertically oriented spring. This implies that measurements of perfusion in vivo will be influenced by density distributions and will differ from excised lungs where density gradients are reduced by processing.

Original languageEnglish (US)
Pages (from-to)240-248
Number of pages9
JournalJournal of Applied Physiology
Volume103
Issue number1
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Perfusion
Lung
Radioactive Tracers
Breath Holding
Functional Residual Capacity
Patents
Microspheres
Protons
Magnetic Resonance Imaging
Weights and Measures

Keywords

  • Functional magnetic resonance imaging
  • Gravity
  • Lung density
  • Lung perfusion

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hopkins, S. R., Henderson, A. C., Levin, D. L., Yamada, K., Arai, T., Buxton, R. B., & Prisk, G. K. (2007). Vertical gradients in regional lung density and perfusion in the supine human lung: The Slinky effect. Journal of Applied Physiology, 103(1), 240-248. https://doi.org/10.1152/japplphysiol.01289.2006

Vertical gradients in regional lung density and perfusion in the supine human lung : The Slinky effect. / Hopkins, Susan R.; Henderson, A. Cortney; Levin, David L.; Yamada, Kei; Arai, Tatsuya; Buxton, Richard B.; Prisk, G. Kim.

In: Journal of Applied Physiology, Vol. 103, No. 1, 07.2007, p. 240-248.

Research output: Contribution to journalArticle

Hopkins, SR, Henderson, AC, Levin, DL, Yamada, K, Arai, T, Buxton, RB & Prisk, GK 2007, 'Vertical gradients in regional lung density and perfusion in the supine human lung: The Slinky effect', Journal of Applied Physiology, vol. 103, no. 1, pp. 240-248. https://doi.org/10.1152/japplphysiol.01289.2006
Hopkins, Susan R. ; Henderson, A. Cortney ; Levin, David L. ; Yamada, Kei ; Arai, Tatsuya ; Buxton, Richard B. ; Prisk, G. Kim. / Vertical gradients in regional lung density and perfusion in the supine human lung : The Slinky effect. In: Journal of Applied Physiology. 2007 ; Vol. 103, No. 1. pp. 240-248.
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