Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia

J. Vincent Filoteo, David P. Salmon, Dawn M. Schiehser, Amy E. Kane, Joanne M. Hamilton, Laurie M. Rilling, John A Lucas, Vanessa Zizak, Douglas R. Galasko

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This study compared verbal learning and memory in patients with autopsy-confirmed dementia with Lewy bodies (DLB) and patients with Parkinson's disease with dementia (PDD). A total of 24 DLB patients, 24 PDD patients, and 24 normal comparison participants were administered the California Verbal Learning Test. The three groups were matched on demographic variables, and the two patient groups were matched on the Mattis Dementia Rating Scale. The results indicated that DLB patients recalled less information than PDD patients on all but one recall measure and displayed a more rapid rate of forgetting. In contrast, the PDD patients committed a greater percentage of perseveration errors than the DLB patients. The two groups did not differ in the percentage of recall intrusion errors or any measures of recognition. A discriminant function analysis (DFA) using short-delay cued recall, percentage of perseveration errors, and List B recall differentiated the DLB and PDD groups with 81.3% accuracy. The application of the DFA algorithm to another sample of 42 PDD patients resulted in a 78.6% correct classification rate. The results suggest that, despite equivalent levels of general cognitive impairment, patients with DLB or PDD exhibit a different pattern of verbal learning and memory deficits.

Original languageEnglish (US)
Pages (from-to)823-834
Number of pages12
JournalJournal of Clinical and Experimental Neuropsychology
Volume31
Issue number7
DOIs
StatePublished - Oct 2009

Fingerprint

Verbal Learning
Parkinson Disease
Dementia
Lewy Body Disease
Discriminant Analysis
Research Design
Memory Disorders
Autopsy
Demography

Keywords

  • Dementia with Lewy bodies
  • Learning
  • Memory
  • Parkinson's disease dementia
  • Subcortical dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Clinical Psychology

Cite this

Filoteo, J. V., Salmon, D. P., Schiehser, D. M., Kane, A. E., Hamilton, J. M., Rilling, L. M., ... Galasko, D. R. (2009). Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia. Journal of Clinical and Experimental Neuropsychology, 31(7), 823-834. https://doi.org/10.1080/13803390802572401

Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia. / Filoteo, J. Vincent; Salmon, David P.; Schiehser, Dawn M.; Kane, Amy E.; Hamilton, Joanne M.; Rilling, Laurie M.; Lucas, John A; Zizak, Vanessa; Galasko, Douglas R.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 31, No. 7, 10.2009, p. 823-834.

Research output: Contribution to journalArticle

Filoteo, JV, Salmon, DP, Schiehser, DM, Kane, AE, Hamilton, JM, Rilling, LM, Lucas, JA, Zizak, V & Galasko, DR 2009, 'Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia', Journal of Clinical and Experimental Neuropsychology, vol. 31, no. 7, pp. 823-834. https://doi.org/10.1080/13803390802572401
Filoteo, J. Vincent ; Salmon, David P. ; Schiehser, Dawn M. ; Kane, Amy E. ; Hamilton, Joanne M. ; Rilling, Laurie M. ; Lucas, John A ; Zizak, Vanessa ; Galasko, Douglas R. / Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia. In: Journal of Clinical and Experimental Neuropsychology. 2009 ; Vol. 31, No. 7. pp. 823-834.
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