Ventricular premature contraction associated with mitral valve prolapse

Background In patients with frequent premature ventricular contractions (PVCs), little is known about the profile of PVCs and the outcome of treatment in patients with mitral valve prolapse (MVP) compared to those without MVP. Methods and results Patients with documented PVCs between January 2001 and October 2012 were divided into 2 groups: MVP and non-MVP. The PVC characteristics, efficacy of therapy, and outcome were compared between the 2 groups. A total of 112 patients with MVP and 952 without MVP were identified. The frequency of PVCs was similar between the 2 groups (P > .05). In patients who underwent cardiac mapping, PVCs originating in papillary muscles (26.7% vs 2.3%; P < .001) and fascicle (13.3% vs 3.4%; P < .001) were more frequently seen in the MVP group than in the non-MVP group, which raises the difficulty of catheter ablation. The 2 groups had similar response to catheter ablation or medical therapy (P > .05). The survival rate was similar between the 2 groups (P = .95). Conclusion In patients with significant PVC burden, MVP patients had similar PVC frequency, treatment outcome, and survival rate to those without MVP.