Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease

Yi Yu Chou, Natasha Leporé, Priya Saharan, Sarah K. Madsen, Xue Hua, Clifford R Jr. Jack, Leslie M. Shaw, John Q. Trojanowski, Michael W. Weiner, Arthur W. Toga, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

There is an urgent need for neuroimaging biomarkers of Alzheimer's disease (AD) that correlate with cognitive decline, and with accepted measures of pathology detectable in cerebrospinal fluid (CSF). Ideal biomarkers should also be able to predict future decline, and should be computable automatically from hundreds to thousands of images without user intervention. Here we used our multiatlas fluid image alignment method (MAFIA [1]), to automatically segment parametric 3D surface models of the lateral ventricles in brain MRI scans from 184 AD, 391 MCI, and 229 healthy elderly controls. Radial expansion of the ventricles, computed pointwise, was correlated with measures of (1) clinical decline, (2) pathology from CSF, and (3) future deterioration. Surface-based correlation maps were assessed using a cumulative distribution function method to rank influential covariates according to their effect sizes. The resulting approach is highly automated, and boosts the power of fluid image registration by integrating multiple independent registrations to reduce segmentation errors.

Original languageEnglish (US)
Title of host publication2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings
Pages241-244
Number of pages4
DOIs
StatePublished - 2010
Event7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands
Duration: Apr 14 2010Apr 17 2010

Other

Other7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
CountryNetherlands
CityRotterdam
Period4/14/104/17/10

Fingerprint

Cerebrospinal fluid
Biomarkers
Pathology
Cerebrospinal Fluid
Alzheimer Disease
Neuroimaging
Fluids
Lateral Ventricles
Image registration
Distribution functions
Deterioration
Brain
Magnetic Resonance Imaging
Cognitive Dysfunction
Power (Psychology)

Keywords

  • ADNI
  • Lateral ventricles
  • MRI

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Chou, Y. Y., Leporé, N., Saharan, P., Madsen, S. K., Hua, X., Jack, C. R. J., ... Thompson, P. M. (2010). Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 241-244). [5490368] https://doi.org/10.1109/ISBI.2010.5490368

Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease. / Chou, Yi Yu; Leporé, Natasha; Saharan, Priya; Madsen, Sarah K.; Hua, Xue; Jack, Clifford R Jr.; Shaw, Leslie M.; Trojanowski, John Q.; Weiner, Michael W.; Toga, Arthur W.; Thompson, Paul M.

2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. p. 241-244 5490368.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chou, YY, Leporé, N, Saharan, P, Madsen, SK, Hua, X, Jack, CRJ, Shaw, LM, Trojanowski, JQ, Weiner, MW, Toga, AW & Thompson, PM 2010, Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease. in 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings., 5490368, pp. 241-244, 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010, Rotterdam, Netherlands, 4/14/10. https://doi.org/10.1109/ISBI.2010.5490368
Chou YY, Leporé N, Saharan P, Madsen SK, Hua X, Jack CRJ et al. Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. p. 241-244. 5490368 https://doi.org/10.1109/ISBI.2010.5490368
Chou, Yi Yu ; Leporé, Natasha ; Saharan, Priya ; Madsen, Sarah K. ; Hua, Xue ; Jack, Clifford R Jr. ; Shaw, Leslie M. ; Trojanowski, John Q. ; Weiner, Michael W. ; Toga, Arthur W. ; Thompson, Paul M. / Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease. 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. pp. 241-244
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