Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart

Toshihiro Tsuruda, Michihisa Jougasaki, Guido Boerrigter, Lisa C. Costello-Boerrigter, Alessandro Cataliotti, Shang C. Lee, Lisa Salz-Gilman, Lynda J. Nordstrom, C. G A McGregor, John C Jr. Burnett

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Adrenomedullin (ADM) is a vasoactive and natriuretic peptide. While it is known that ADM is increased in failing human ventricles, the expression of ADM in human ventricular allografts remains unknown. The present study was designed to investigate tissue localization and intensity of ADM expression in ventricular biopsy specimens and to characterize ventricular ADM in human cardiac allografts. Thirty-three post-transplant endomyocardial biopsy specimens were examined immunohistochemically. The average score (range: 0-4) of ADM immunoreactivity (IR) was 2.4±0.9 (mean±standard deviation). Right ventricular (RV) systolic pressure was significantly increased with high ADM-IR (p=0.048) and the ADM-IR positively associated with myocyte size (r2=0.23, p=0.010). In contrast, ADM-IR was not associated with systemic blood pressure, serum creatinine, cyclosporine concentration, cardiac fibrosis, or allograft rejection. The present study shows that ADM-IR is present in human ventricular endomyocardium after transplantation, and ADM-IR is associated with the magnitude of RV pressure and myocyte size, suggesting an important role for ventricular ADM in the counteraction against overload as well as in the progress of myocyte hypertrophy after heart transplantation.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalRegulatory Peptides
Volume112
Issue number1-3
DOIs
StatePublished - Apr 15 2003

Fingerprint

Adrenomedullin
Muscle Cells
Hypertrophy
Allografts
Ventricular Pressure
Biopsy
Blood Pressure
Natriuretic Peptides
Heart Transplantation
Transplants
Blood pressure
Cyclosporine
Creatinine
Fibrosis
Transplantation

Keywords

  • Adrenomedullin
  • Heart transplantation
  • Human
  • Hypertrophy
  • Rejection

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Tsuruda, T., Jougasaki, M., Boerrigter, G., Costello-Boerrigter, L. C., Cataliotti, A., Lee, S. C., ... Burnett, J. C. J. (2003). Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart. Regulatory Peptides, 112(1-3), 161-166. https://doi.org/10.1016/S0167-0115(03)00035-1

Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart. / Tsuruda, Toshihiro; Jougasaki, Michihisa; Boerrigter, Guido; Costello-Boerrigter, Lisa C.; Cataliotti, Alessandro; Lee, Shang C.; Salz-Gilman, Lisa; Nordstrom, Lynda J.; McGregor, C. G A; Burnett, John C Jr.

In: Regulatory Peptides, Vol. 112, No. 1-3, 15.04.2003, p. 161-166.

Research output: Contribution to journalArticle

Tsuruda, T, Jougasaki, M, Boerrigter, G, Costello-Boerrigter, LC, Cataliotti, A, Lee, SC, Salz-Gilman, L, Nordstrom, LJ, McGregor, CGA & Burnett, JCJ 2003, 'Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart', Regulatory Peptides, vol. 112, no. 1-3, pp. 161-166. https://doi.org/10.1016/S0167-0115(03)00035-1
Tsuruda T, Jougasaki M, Boerrigter G, Costello-Boerrigter LC, Cataliotti A, Lee SC et al. Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart. Regulatory Peptides. 2003 Apr 15;112(1-3):161-166. https://doi.org/10.1016/S0167-0115(03)00035-1
Tsuruda, Toshihiro ; Jougasaki, Michihisa ; Boerrigter, Guido ; Costello-Boerrigter, Lisa C. ; Cataliotti, Alessandro ; Lee, Shang C. ; Salz-Gilman, Lisa ; Nordstrom, Lynda J. ; McGregor, C. G A ; Burnett, John C Jr. / Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart. In: Regulatory Peptides. 2003 ; Vol. 112, No. 1-3. pp. 161-166.
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