Ventilator-induced lung injury: Minimizing its impact in patients with or at risk for ARDS

Michelle Biehl, Markos G. Kashiouris, Ognjen Gajic

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Ventilator-induced lung injury (VILI) results from injury to the blood-gas barrier caused by mechanical ventilation. The determinants of VILI are more complex than originally thought, and include the nature, duration, and intensity of the exposure, as well the pattern of initial insult to the lung. Lung-protective mechanical ventilation founded on these basic principles resulted in improved hospital and long-term mortality. The purpose of this review is to provide a comprehensive assessment of the pathogenesis of VILI and its determinants. We also discuss the best preventive approach in patients with or at risk for ARDS and critically appraise the most recent evidence, expert opinion, and implementation of the acquired knowledge to the bedside.

Original languageEnglish (US)
Pages (from-to)927-934
Number of pages8
JournalRespiratory care
Issue number6
StatePublished - Jun 1 2013


  • ARDS
  • Mechanical ventilation
  • Prevention
  • Tidal volume
  • VILI
  • Ventilator-induced lung injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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