Ventilator-induced lung injury: In vivo and in vitro mechanisms

Michael A. Matthay, Sunita Bhattacharya, Donald Gaver, Lorraine B. Ware, Lina H K Lim, Olga Syrkina, Fabien Eyal, Rolf Hubmayr

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume283
Issue number4 27-4
StatePublished - Oct 2002

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Ventilator-Induced Lung Injury
Lung
Mechanical Stress
Acute Lung Injury
Mechanical Ventilators
Endothelium
Neutrophils
Epithelium
Macrophages
Mortality
In Vitro Techniques

Keywords

  • Acute lung injury
  • Macrophages
  • Neutrophils

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cell Biology
  • Physiology

Cite this

Matthay, M. A., Bhattacharya, S., Gaver, D., Ware, L. B., Lim, L. H. K., Syrkina, O., ... Hubmayr, R. (2002). Ventilator-induced lung injury: In vivo and in vitro mechanisms. American Journal of Physiology - Lung Cellular and Molecular Physiology, 283(4 27-4).

Ventilator-induced lung injury : In vivo and in vitro mechanisms. / Matthay, Michael A.; Bhattacharya, Sunita; Gaver, Donald; Ware, Lorraine B.; Lim, Lina H K; Syrkina, Olga; Eyal, Fabien; Hubmayr, Rolf.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 283, No. 4 27-4, 10.2002.

Research output: Contribution to journalArticle

Matthay, MA, Bhattacharya, S, Gaver, D, Ware, LB, Lim, LHK, Syrkina, O, Eyal, F & Hubmayr, R 2002, 'Ventilator-induced lung injury: In vivo and in vitro mechanisms', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 283, no. 4 27-4.
Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LHK, Syrkina O et al. Ventilator-induced lung injury: In vivo and in vitro mechanisms. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2002 Oct;283(4 27-4).
Matthay, Michael A. ; Bhattacharya, Sunita ; Gaver, Donald ; Ware, Lorraine B. ; Lim, Lina H K ; Syrkina, Olga ; Eyal, Fabien ; Hubmayr, Rolf. / Ventilator-induced lung injury : In vivo and in vitro mechanisms. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2002 ; Vol. 283, No. 4 27-4.
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