Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty

Christopher M. Duncan, Blake P. Gillette, Adam K. Jacob, Rafael J. Sierra, Joaquin Sanchez-Sotelo, Hugh M. Smith

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR = 0.98; 95% CI 0.67-1.45; P = 0.939) or adjusted odds of death (OR = 0.26; 95% CI 0.04-1.80; P = 0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalJournal of Arthroplasty
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Tranexamic Acid
Tacrine
Knee Replacement Arthroplasties
Venous Thromboembolism
Hip
Mortality
Blood Transfusion
Orthopedics
Cohort Studies
Retrospective Studies

Keywords

  • Hip arthroplasty
  • Knee arthroplasty
  • Mortality
  • Tranexamic acid
  • Venothromboembolism

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Medicine(all)

Cite this

Duncan, C. M., Gillette, B. P., Jacob, A. K., Sierra, R. J., Sanchez-Sotelo, J., & Smith, H. M. (2015). Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. Journal of Arthroplasty, 30(2), 272-276. https://doi.org/10.1016/j.arth.2014.08.022

Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. / Duncan, Christopher M.; Gillette, Blake P.; Jacob, Adam K.; Sierra, Rafael J.; Sanchez-Sotelo, Joaquin; Smith, Hugh M.

In: Journal of Arthroplasty, Vol. 30, No. 2, 01.02.2015, p. 272-276.

Research output: Contribution to journalArticle

Duncan, CM, Gillette, BP, Jacob, AK, Sierra, RJ, Sanchez-Sotelo, J & Smith, HM 2015, 'Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty', Journal of Arthroplasty, vol. 30, no. 2, pp. 272-276. https://doi.org/10.1016/j.arth.2014.08.022
Duncan, Christopher M. ; Gillette, Blake P. ; Jacob, Adam K. ; Sierra, Rafael J. ; Sanchez-Sotelo, Joaquin ; Smith, Hugh M. / Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. In: Journal of Arthroplasty. 2015 ; Vol. 30, No. 2. pp. 272-276.
@article{a5244a2fe0244e08b8ebea6ee7b7b999,
title = "Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty",
abstract = "TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR = 0.98; 95{\%} CI 0.67-1.45; P = 0.939) or adjusted odds of death (OR = 0.26; 95{\%} CI 0.04-1.80; P = 0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.",
keywords = "Hip arthroplasty, Knee arthroplasty, Mortality, Tranexamic acid, Venothromboembolism",
author = "Duncan, {Christopher M.} and Gillette, {Blake P.} and Jacob, {Adam K.} and Sierra, {Rafael J.} and Joaquin Sanchez-Sotelo and Smith, {Hugh M.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.arth.2014.08.022",
language = "English (US)",
volume = "30",
pages = "272--276",
journal = "Journal of Arthroplasty",
issn = "0883-5403",
publisher = "Churchill Livingstone",
number = "2",

}

TY - JOUR

T1 - Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty

AU - Duncan, Christopher M.

AU - Gillette, Blake P.

AU - Jacob, Adam K.

AU - Sierra, Rafael J.

AU - Sanchez-Sotelo, Joaquin

AU - Smith, Hugh M.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR = 0.98; 95% CI 0.67-1.45; P = 0.939) or adjusted odds of death (OR = 0.26; 95% CI 0.04-1.80; P = 0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.

AB - TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR = 0.98; 95% CI 0.67-1.45; P = 0.939) or adjusted odds of death (OR = 0.26; 95% CI 0.04-1.80; P = 0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.

KW - Hip arthroplasty

KW - Knee arthroplasty

KW - Mortality

KW - Tranexamic acid

KW - Venothromboembolism

UR - http://www.scopus.com/inward/record.url?scp=84925042467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925042467&partnerID=8YFLogxK

U2 - 10.1016/j.arth.2014.08.022

DO - 10.1016/j.arth.2014.08.022

M3 - Article

VL - 30

SP - 272

EP - 276

JO - Journal of Arthroplasty

JF - Journal of Arthroplasty

SN - 0883-5403

IS - 2

ER -